Department of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Int J Endocrinol. 2013;2013:239376. doi: 10.1155/2013/239376. Epub 2013 Oct 12.
Objective. To examine whether anthropometric measures could predict diabetes incidence in a Chinese population during a 15-year follow-up. Design and Methods. The data were collected in 1992 and then again in 2007 from the same group of 687 individuals. Waist circumference, body mass index, waist to hip ratio, and waist to height ratio were collected based on a standard protocol. To assess the effects of baseline anthropometric measures on the new onset of diabetes, Cox's proportional hazards regression models were used to estimate the hazard ratios of them, and the discriminatory power of anthropometric measures for diabetes was assessed by the area under the receiver operating curve (AROC). Results. Seventy-four individuals were diagnosed with diabetes during a 15-year follow-up period (incidence: 10.8%). These anthropometric measures also predicted future diabetes during a long follow-up (P < 0.001). At 7-8 years, the AROC of central obesity measures (WC, WHpR, WHtR) were higher than that of general obesity measures (BMI) (P < 0.05). But, there were no significant differences among the four anthropometric measurements at 15 years. Conclusions. These anthropometric measures could still predict diabetes with a long time follow-up. However, the validity of anthropometric measures to predict incident diabetes may change with time.
目的。本研究旨在探讨在 15 年的随访中,人体测量学指标是否可预测中国人糖尿病的发病情况。
设计与方法。本研究的数据来源于同一组 687 名个体,他们在 1992 年和 2007 年分别接受了两次调查。腰围、体重指数、腰臀比和腰高比均按照标准方案进行测量。为了评估基线人体测量学指标对新发糖尿病的影响,采用 Cox 比例风险回归模型来估计这些指标的风险比,并通过接收者操作特征曲线下面积(AROC)评估人体测量学指标对糖尿病的判别能力。
结果。在 15 年的随访期间,有 74 人被诊断患有糖尿病(发病率:10.8%)。这些人体测量学指标在长期随访中也可预测未来的糖尿病(P < 0.001)。在 7-8 年时,中心性肥胖指标(WC、WHpR、WHtR)的 AROC 高于一般性肥胖指标(BMI)(P < 0.05)。但是,在 15 年时,这四种人体测量学指标之间没有显著差异。
结论。这些人体测量学指标仍可预测长时间随访中的糖尿病发病情况。然而,人体测量学指标预测新发糖尿病的有效性可能会随时间而变化。