Sayyah Mehdi, Siahpoosh Amir, Khalili Hamidreza, Malayeri Alireza, Samaee Hamidreza
Herbal Medicine Research Center, Jundishapur University of Medical Sciences, Ahwaz, Iran.
Iran J Pharm Res. 2012 Spring;11(2):697-701.
The aim of this study was to assess the efficacy and tolerability of the aqueous extract of Echium amoenum in combination with SSRIs in patients with General Anxiety Disorder (GAD). The study was an 8-week double-blind randomized clinical trial. Thirty-seven adult outpatients who met the DSM-IV-TR criteria for GAD based on the structured clinical interview participated in the trial. In this study, patients were randomly assigned to receive the aqueous extract (500 mg) plus fluoxetine or fluoxetine (20 mg/day) plus placebo. The results showed significant difference between the two groups in the treatment of GAD. Moreover, there was not any significant difference between the two groups in terms of observed side effects. E. amoenum is effective on anxiety disorder, especially in higher dosage, without any serious side effects.
本研究的目的是评估紫锥菊水提取物与选择性5-羟色胺再摄取抑制剂（SSRI）联合使用对广泛性焦虑症（GAD）患者的疗效和耐受性。该研究是一项为期8周的双盲随机临床试验。37名基于结构化临床访谈符合DSM-IV-TR广泛性焦虑症标准的成年门诊患者参与了该试验。在本研究中，患者被随机分配接受水提取物（500毫克）加氟西汀或氟西汀（20毫克/天）加安慰剂。结果显示，两组在广泛性焦虑症的治疗上有显著差异。此外，两组在观察到的副作用方面没有任何显著差异。紫锥菊对焦虑症有效，尤其是在高剂量时，且没有任何严重的副作用。
