Schack M, Sachse S, Rödel J, Frangoulidis D, Pletz M W, Rohde G U, Straube E, Boden K
Institute of Medical Microbiology,University Hospital Jena,Germany.
Bundeswehr Institute of Microbiology,Munich,Germany.
Epidemiol Infect. 2014 Sep;142(9):1905-10. doi: 10.1017/S0950268813002914. Epub 2013 Nov 20.
Q fever is a notifiable disease in Germany. The majority of the reported cases are related to outbreaks. The objective of our study was to evaluate the general role of Q fever in community-acquired pneumonia (CAP). We investigated respiratory samples and sera from 255 patients with CAP, who were enrolled into a CAPNETZ cohort in summer 2005. Altogether, our data showed a significant prevalence of Q fever as CAP (3·5%). If a patient's condition leads to a diagnostic test for Chlamydophila sp., Mycoplasma sp. or Legionella sp., then a Q fever diagnostic test should also be included. In particular, ELISA as a first diagnostic step is easy to perform. PCR should be performed at an early stage of the disease if no antibodies are detectable. Because of our highly promising findings we suggest performing PCR in respiratory samples.
在德国，Q热是一种应报告的疾病。报告的大多数病例与疫情爆发有关。我们研究的目的是评估Q热在社区获得性肺炎（CAP）中的总体作用。我们调查了2005年夏季纳入CAPNETZ队列的255例CAP患者的呼吸道样本和血清。总体而言，我们的数据显示Q热作为CAP的患病率显著（3.5%）。如果患者的病情导致对嗜衣原体属、支原体属或军团菌属进行诊断检测，那么也应包括Q热诊断检测。特别是，ELISA作为第一步诊断方法易于操作。如果未检测到抗体，应在疾病早期进行PCR检测。鉴于我们极具前景的研究结果，我们建议对呼吸道样本进行PCR检测。
