Ulanova A M, Chukhrov A D, Shal'nova G A, Klemparskaia N N, Kuz'mina T D
Zh Mikrobiol Epidemiol Immunobiol. 1986 May(5):73-7.
Experiments on 2,520 CBA mice (CBA X X C57BL) F1 nice have shown that the injection of homologous serum immunoglobulins (obtained from intact and blood-stimulated animals), made 2 hours after gamma irradiation from a 60Co source, prevents the development of intestinal dysbacteriosis and endogenous infection. The injection of mouse and human immunoglobulins to nonirradiated mice improved their resistance to experimental infection with Escherichia coli live culture, increased the expression of receptors to the Fc-fragments of IgG in peritoneal macrophages and enhanced the physical working capacity of the animals. The preparations containing normal antitissular antibodies have proved to be particularly effective. In mice, rabbits and dogs the preparations under test have produced no changes in the general state of the animals, no local reactions and no disturbances in the cardiovascular activity.
对2520只（CBA×C57BL）F1代CBA小鼠进行的实验表明，在60Co源γ射线照射后2小时注射同源血清免疫球蛋白（从完整和受血液刺激的动物获得），可预防肠道菌群失调和内源性感染的发生。向未受照射的小鼠注射小鼠和人免疫球蛋白可提高它们对大肠杆菌活菌培养实验性感染的抵抗力，增加腹膜巨噬细胞中IgG Fc片段受体的表达，并增强动物的体力工作能力。已证明含有正常抗组织抗体的制剂特别有效。在小鼠、兔子和狗身上，受试制剂未引起动物一般状态的变化、局部反应或心血管活动的紊乱。
