Masini E, Lodovici M, Fantozzi R, Brunelleschi S, Conti A, Mannaioni P F
Agents Actions. 1986 Apr;18(1-2):85-8. doi: 10.1007/BF01987990.
The incubation of paracetamol with isolated rat serosal mast cells evokes the release of histamine only in the presence of (S10) liver microsomes obtained from PCB or phenobarbital treated rats. The release of histamine was not accompanied by a leakage of lactate dehydrogenase and was blocked by the antioxidant alpha-tocopherol and by D-mannitol, an hydroxyl free radicals scavenger. The data are consistent with the metabolic oxidation of paracetamol in the generation of reactive intermediates capable of activating the sequential exocytosis.
对乙酰氨基酚与分离出的大鼠浆膜肥大细胞一起温育时，只有在存在从多氯联苯或苯巴比妥处理的大鼠获得的（S10）肝微粒体的情况下才会引起组胺释放。组胺的释放并未伴有乳酸脱氢酶的泄漏，并且被抗氧化剂α-生育酚和羟基自由基清除剂D-甘露醇所阻断。这些数据与对乙酰氨基酚在生成能够激活连续胞吐作用的反应性中间体过程中的代谢氧化作用一致。
