评估过表达鹿朊病毒蛋白的转基因小鼠对牛海绵状脑病的易感性。
Assessing the susceptibility of transgenic mice overexpressing deer prion protein to bovine spongiform encephalopathy.
机构信息
Animal Health and Veterinary Laboratories Agency (AHVLA) Weybridge, Addlestone, Surrey, United Kingdom.
出版信息
J Virol. 2014 Feb;88(3):1830-3. doi: 10.1128/JVI.02762-13. Epub 2013 Nov 20.
Abstract
Several transgenic mouse models have been developed which facilitate the transmission of chronic wasting disease (CWD) of cervids and allow prion strain discrimination. The present study was designed to assess the susceptibility of the prototypic mouse line, Tg(CerPrP)1536(+/-), to bovine spongiform encephalopathy (BSE) prions, which have the ability to overcome species barriers. Tg(CerPrP)1536(+/-) mice challenged with red deer-adapted BSE resulted in 90% to 100% attack rates, and BSE from cattle failed to transmit, indicating agent adaptation in the deer.
摘要
已经开发了几种转基因小鼠模型，这些模型有助于传播鹿慢性消耗病（CWD），并允许朊病毒株的区分。本研究旨在评估原型小鼠系 Tg(CerPrP)1536(+/-)对牛海绵状脑病（BSE）朊病毒的易感性，BSE 朊病毒具有克服物种障碍的能力。用经过驯鹿适应性改造的 BSE 对 Tg(CerPrP)1536(+/-) 小鼠进行攻击，导致 90%至 100%的攻击率，而牛源 BSE 未能传播，表明 deer 中存在适应物。
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