Bishop A E, Polak J M, Bauer F E, Christofides N D, Carlei F, Bloom S R
Gut. 1986 Jul;27(7):849-57. doi: 10.1136/gut.27.7.849.
Galanin, a newly discovered peptide, was found throughout the gastrointestinal tract of man, pig, and rat, exclusively in nerves. The concentrations of immunoreactive galanin ranged from 3.7 +/- 0.7 (mean +/- SEM) pmol/g in rat antrum to 76.5 +/- 14.3 pmol/g in pig colon. The predominantly intrinsic origin of the galanin nerves was shown by the finding of the peptide in submucosal ganglion cells, the majority of which also contained VIP. Furthermore, neither extrinsic denervation of the gut nor administration of capsaicin, which selectively destroys extrinsic afferent fibres, had any significant effect on the galanin innervation. The caudal projection of galanin-immunoreactive fibres was demonstrated by complete transection of the gut, which led to their reduction in the 1 to 2 cm distal to the cut. The abundance of galanin in the innervation of the mammalian gut and its reported action on smooth muscle contractility suggest this peptide to be a novel regulatory factor in the control of bowel function.
甘丙肽是一种新发现的肽，在人、猪和大鼠的整个胃肠道中均有发现，且仅存在于神经中。免疫反应性甘丙肽的浓度范围为：大鼠胃窦为3.7±0.7（平均值±标准误）pmol/g，猪结肠为76.5±14.3 pmol/g。甘丙肽神经主要起源于内在神经，这一点可通过在黏膜下神经节细胞中发现该肽得到证明，其中大多数细胞也含有血管活性肠肽（VIP）。此外，肠道的外在去神经支配以及给予辣椒素（可选择性破坏外在传入纤维）对甘丙肽神经支配均无显著影响。通过完全横断肠道证明了甘丙肽免疫反应性纤维的向尾投射，这导致在切口远端1至2厘米处其数量减少。甘丙肽在哺乳动物肠道神经支配中的丰富含量及其对平滑肌收缩性的报道作用表明，该肽是控制肠道功能的一种新型调节因子。
