UCD Nanomedicine Centre, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
Integr Biol (Camb). 2014 Jan;6(1):27-34. doi: 10.1039/c3ib40185e.
Magnetic tweezers (MTW) enable highly accurate forces to be transduced to molecules to study mechanotransduction at the molecular or cellular level. We review recent MTW studies in single molecule and cell biophysics that demonstrate the flexibility of this technique. We also discuss technical advances in the method on several fronts, i.e., from novel approaches for the measurement of torque to multiplexed biophysical assays. Finally, we describe multi-component nanorods with enhanced optical and magnetic properties and discuss their potential as future MTW probes.
磁镊（MTW）能够将高精度的力转化为分子，从而在分子或细胞水平上研究力学转导。我们综述了单分子和细胞生物物理学中最近的 MTW 研究，这些研究展示了该技术的灵活性。我们还讨论了该方法在几个方面的技术进展，例如，从用于测量扭矩的新方法到多路复用生物物理测定。最后，我们描述了具有增强的光学和磁性能的多组分纳米棒，并讨论了它们作为未来 MTW 探针的潜力。
