Section for Epidemiology, Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000 Aarhus C, Denmark.
Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.
Br J Nutr. 2014 Apr 14;111(7):1283-91. doi: 10.1017/S0007114513003747. Epub 2013 Nov 29.
Previous studies have suggested that the intake of trans-fatty acids (TFA) plays a role in the development of obesity. The proportions of adipose tissue fatty acids not synthesised endogenously in humans, such as TFA, usually correlate well with the dietary intake. Hence, the use of these biomarkers may provide a more accurate measure of habitual TFA intake than that obtained with dietary questionnaires. The objective of the present study was to investigate the associations between the proportions of specific TFA in adipose tissue and subsequent changes in weight and waist circumference (WC). The relative content of fatty acids in adipose tissue biopsies from a random sample of 996 men and women aged 50-64 years drawn from a Danish cohort study was determined by GC. Baseline data on weight, WC and potential confounders were available together with information on weight and WC 5 years after enrolment. The exposure measures were total trans-octadecenoic acids (18:1t), 18:1 Δ6-10t, vaccenic acid (18:1 Δ11t) and rumenic acid (18:2 Δ9c, 11t). Data were analysed using multiple regression with cubic spline modelling. The median proportion of total adipose tissue 18:1t was 1.52% (90% central range 0.98, 2.19) in men and 1.47% (1.01, 2.19) in women. No significant associations were observed between the proportions of total 18:1t, 18:1 Δ6-10t, vaccenic acid or rumenic acid and changes in weight or WC. The present study suggests that the proportions of specific TFA in adipose tissue are not associated with subsequent changes in weight or WC within the exposure range observed in this population.
先前的研究表明，反式脂肪酸（TFA）的摄入与肥胖的发展有关。在人类中，不是内源性合成的脂肪组织脂肪酸（如 TFA）的比例通常与饮食摄入密切相关。因此，使用这些生物标志物可能比通过饮食问卷获得的更能准确衡量习惯性 TFA 的摄入量。本研究旨在调查脂肪组织中特定 TFA 比例与随后体重和腰围（WC）变化之间的关联。通过 GC 测定了从丹麦队列研究中随机抽取的 996 名 50-64 岁男性和女性的脂肪组织活检中脂肪酸的相对含量。基线数据包括体重、WC 和潜在混杂因素，以及入组 5 年后的体重和 WC 信息。暴露测量值为总反式十八碳烯酸（18:1t）、18:1 Δ6-10t、vaccenic 酸（18:1 Δ11t）和 rumenic 酸（18:2 Δ9c，11t）。使用多元回归和三次样条模型进行数据分析。男性脂肪组织中总 18:1t 的中位数比例为 1.52%（90%中心范围为 0.98%，2.19%），女性为 1.47%（1.01%，2.19%）。在体重或 WC 方面，未观察到总 18:1t、18:1 Δ6-10t、vaccenic 酸或 rumenic 酸的比例与变化之间存在显著关联。本研究表明，在该人群观察到的暴露范围内，脂肪组织中特定 TFA 的比例与随后的体重或 WC 变化无关。
