Laboratory of Environmental and Applied Chemistry, Faculty of Science, University of Dschang, P.O. Box 183, Dschang, Cameroon; Laboratory of Biochemistry of Medicinal Plants, Food Science and Nutrition, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Food Chem. 2014 Apr 15;149:183-9. doi: 10.1016/j.foodchem.2013.10.093. Epub 2013 Oct 30.
Fruits of Xylopia parviflora, well known as striped African pepper, are sold in the Cameroonian markets as a flavouring ingredient to make traditional soups. The essential oil hydrodistilled from fruits was analysed for in vitro biological activities, namely cytotoxic, anti-inflammatory, antimicrobial and antioxidant, by MTT, nitric oxide inhibitory assay, agar disc diffusion method, and DPPH and ABTS assays. The essential oil composition, analysed by GC and GC-MS, was dominated by monoterpene hydrocarbons (50.0%) responsible for the pepper odour, such as β-pinene (34.0%) and α-pinene (10.3%). The oil induced a strong inhibitory effect on tumour cells MDA-MB 231 and HCT116, with inhibition values close to those of cisplatin. A dose-dependent decrease in NO production was noted in RAW 264.7 macrophages treated with the oil, revealing a promising anti-inflammatory potential. The essential oil showed a measurable antimicrobial activity against all the species tested, while the radical scavenging activity was low.
狭叶非洲椒的果实，俗称条纹非洲椒，在喀麦隆市场上作为调味成分出售，用于制作传统汤品。从果实中通过水蒸馏法提取的精油，通过 MTT、一氧化氮抑制试验、琼脂圆盘扩散法以及 DPPH 和 ABTS 试验，评估了其体外生物活性，包括细胞毒性、抗炎、抗菌和抗氧化活性。通过 GC 和 GC-MS 分析的精油成分以单萜烃（50.0%）为主，这些成分赋予了油胡椒的气味，如β-蒎烯（34.0%）和α-蒎烯（10.3%）。该油对肿瘤细胞 MDA-MB 231 和 HCT116 具有强烈的抑制作用，其抑制值接近于顺铂。用该油处理 RAW 264.7 巨噬细胞后，NO 产生呈剂量依赖性下降，显示出有希望的抗炎潜力。该精油对所有测试的物种均表现出可衡量的抗菌活性，而自由基清除活性较低。
