Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minn.
Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minn.
Transl Res. 2014 Apr;163(4):409-17. doi: 10.1016/j.trsl.2013.11.006. Epub 2013 Nov 14.
Conditions involving muscle wasting, such as muscular dystrophies, cachexia, and sarcopenia, would benefit from approaches that promote skeletal muscle regeneration. Stem cells are particularly attractive because they are able to differentiate into specialized cell types while retaining the ability to self-renew and, thus, provide a long-term response. This review will discuss recent advancements on different types of stem cells that have been attributed to be endowed with muscle regenerative potential. We will discuss the nature of these cells and their advantages and disadvantages in regards to therapy for muscular dystrophies.
涉及肌肉消耗的病症,如肌肉营养不良、恶病质和肌肉减少症,将受益于促进骨骼肌再生的方法。干细胞特别有吸引力,因为它们能够分化为特化的细胞类型,同时保持自我更新的能力,从而提供长期的反应。本综述将讨论不同类型的干细胞在肌肉再生潜力方面的最新进展。我们将讨论这些细胞的性质及其在肌肉营养不良治疗方面的优缺点。