白蛉唾液-利什曼原虫-人类：引发疾病的三联因素。
Sand-fly saliva-leishmania-man: the trigger trio.
作者信息
Oliveira Fabiano, de Carvalho Augusto M, de Oliveira Camila I
机构信息
Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, MD , USA.
出版信息
Front Immunol. 2013 Nov 19;4:375. doi: 10.3389/fimmu.2013.00375.
Abstract
Leishmaniases are worldwide diseases transmitted to the vertebrate host by the bite of an infected sand-fly. Sand-fly biting and parasite inoculation are accompanied by the injection of salivary molecules, whose immunomodulatory properties are actively being studied. This mini review focuses on how the interactions between sand-fly saliva and the immune system may shape the outcome of infection, given its immunomodulatory properties, in experimental models and in the endemic area. Additionally, we approach the recent contributions regarding the identification of individual salivary components and how these are currently being considered as additional components of a vaccine against leishmaniasis.
摘要
利什曼病是一种全球性疾病，通过受感染白蛉的叮咬传播给脊椎动物宿主。白蛉叮咬和寄生虫接种伴随着唾液分子的注入，其免疫调节特性正在积极研究中。鉴于其免疫调节特性，本综述聚焦于在实验模型和流行地区中，白蛉唾液与免疫系统之间的相互作用如何影响感染结果。此外，我们探讨了在鉴定单个唾液成分方面的最新进展，以及目前如何将这些成分视为抗利什曼病疫苗的额外成分。
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