Lausten-Thomsen Ulrik, Nielsen Tenna Ruest Haarmark, Thagaard Ida Näslund, Larsen Torben, Holm Jens-Christian
The Children's Obesity Clinic, Department of Paediatrics, Copenhagen University Hospital Holbaek, Smedelundsgade 60, 4300, Holbaek, Denmark,
Eur J Pediatr. 2014 May;173(5):623-7. doi: 10.1007/s00431-013-2226-x. Epub 2013 Dec 7.
Epidemiological and animal studies have suggested an effect of the intrauterine milieu upon the development of childhood obesity. This study investigates the relationship between body composition measured by dual energy X-ray absorptiometry expressed as body fat percent, body fat mass index (BFMI), and fat free mass index (FFMI) in obese children and the preceding in utero conditions expressed by birth weight, birth length, and birth weight for gestational age. The study cohort consisted of 776 obese Danish children (median age 11.6 years, range 3.6-17.9) with a mean Body Mass Index Standard Deviation Score (BMI SDS) of 2.86 (range 1.64-5.48) treated in our national referral centre. In a linear general regression model adjusted for age, gender, socioeconomic status, and duration of breastfeeding, we found the body fat percent, FFMI, and BFMI at the time of enrolment in childhood obesity treatment to be significantly correlated with both birth weight and birth weight for gestational age.
These results indicate a prenatal influence upon childhood obesity. Although there are currently no sufficient data to suggest any recommendations to pregnant women, it is possible that the prenatal period may be considered as a potential window of opportunity for prevention of childhood overweight and obesity.
流行病学和动物研究表明，子宫内环境对儿童肥胖的发展有影响。本研究调查了肥胖儿童中通过双能X线吸收法测量的身体成分（以体脂百分比、体脂质量指数（BFMI）和去脂体重指数（FFMI）表示）与出生体重、出生身长和胎龄出生体重所表示的先前子宫内状况之间的关系。研究队列包括776名肥胖丹麦儿童（中位年龄11.6岁，范围3.6 - 17.9岁），他们在我们国家转诊中心接受治疗，平均体重指数标准差评分（BMI SDS）为2.86（范围1.64 - 5.48）。在调整了年龄、性别、社会经济地位和母乳喂养持续时间的线性一般回归模型中，我们发现儿童肥胖治疗入组时的体脂百分比、FFMI和BFMI与出生体重和胎龄出生体重均显著相关。
这些结果表明产前对儿童肥胖有影响。尽管目前没有足够的数据向孕妇提出任何建议，但产前时期有可能被视为预防儿童超重和肥胖的潜在机会窗口。
