Khawaja Ali, Rao Santosh, Li Li, Thompson Cheryl L
Medical College, The Aga Khan University Hospital, Karachi 74800, Pakistan.
J Cancer Epidemiol. 2013;2013:467927. doi: 10.1155/2013/467927. Epub 2013 Nov 4.
Emerging evidence suggests that short sleep is associated with an increased risk of cancer; however, little has been done to study the role of sleep on tumor characteristics. In this study, we evaluated the relationship between sleep duration and tumor phenotype in 972 breast cancer patients. Sleep duration was inversely associated with tumor grade (univariate P = 0.032), particularly in postmenopausal women (univariate P = 0.018). This association did not reach statistical significance after adjustments for age, race, body mass index, hormone replacement therapy use, alcohol consumption, smoking, and physical activity in the entire study sample (P = 0.052), but it remained statistically significant (P = 0.049) among post-menopausal patients. We did not observe a statistically significant association between sleep duration and stage at diagnosis, ER, or HER2 receptor status. These results present a modest association between short duration of sleep and higher grade breast cancer in post-menopausal women. Further work needs to be done to validate these findings.
新出现的证据表明，睡眠不足与患癌风险增加有关；然而，关于睡眠对肿瘤特征的作用，目前研究较少。在本研究中，我们评估了972例乳腺癌患者的睡眠时间与肿瘤表型之间的关系。睡眠时间与肿瘤分级呈负相关（单变量P = 0.032），尤其是在绝经后女性中（单变量P = 0.018）。在对整个研究样本中的年龄、种族、体重指数、激素替代疗法使用情况、饮酒、吸烟和身体活动进行调整后，这种关联未达到统计学显著性（P = 0.052），但在绝经后患者中仍具有统计学显著性（P = 0.049）。我们未观察到睡眠时间与诊断分期、雌激素受体（ER）或人表皮生长因子受体2（HER2）受体状态之间存在统计学显著性关联。这些结果表明，绝经后女性睡眠时间短与乳腺癌分级较高之间存在适度关联。需要进一步开展工作以验证这些发现。
