Influence of histone-chondroitin sulphate A complexes on blood platelet aggregation.

The influence of histones and their complexes with chondroitin sulphate A on platelet aggregation was studied. Histones F1 and F2a1 and complex histone F1-chondroitin sulphate A do not induce platelet aggregation by themselves but they decreased threshold aggregating concentration of ADP whereas complex histone F2a1-chondroitin sulphate A increased it. The results of our study may point out to the possibility of the examined substances taking part in disturbances of the platelet function.