Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (China), Fax: (+86) 431-85262625; University of Chinese Academy of Sciences, Beijing, 100039 (China).
Chemistry. 2014 Jan 7;20(2):394-8. doi: 10.1002/chem.201303964. Epub 2013 Dec 10.
An antibacterial platform based on multifunctional reduced graphene oxide (rGO) that is responsive to near-infrared (NIR) light has been constructed. By introducing a luminescent Eu(3+) complex and vancomycin for bacteria tracking into one system, this platform could specifically recognize and light up bacteria. Antibacterial activity of this nanoscale construction under NIR illumination was investigated. Upon illumination with NIR light, this nanoscale architecture generates great heat locally, resulting in the death of drug-resistant bacteria. These results indicate that the ability of this nanoscale platform to kill drug-resistant bacteria has great potential for clinical pathogenic bacteria diagnosis and treatment.
构建了一种基于多功能还原氧化石墨烯（rGO）的抗菌平台，该平台对近红外（NIR）光有响应。通过将发光的 Eu(3+)配合物和万古霉素引入到一个系统中，该平台可以特异性地识别和点亮细菌。研究了该纳米结构在 NIR 光照下的抗菌活性。在 NIR 光照射下，这种纳米结构会在局部产生大量热量，导致耐药菌死亡。这些结果表明，该纳米平台杀死耐药菌的能力在临床病原菌诊断和治疗方面具有很大的应用潜力。
