Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, QC H3G 1A6, Canada.
Skelet Muscle. 2013 Dec 16;3(1):29. doi: 10.1186/2044-5040-3-29.
Heterotopic ossification (HO) is defined as the abnormal formation of mature bone in soft tissue, notably skeletal muscle. The morbidity of HO in polytraumatized patients impacts the functional outcome, impairs rehabilitation, and increases costs due to subsequent surgical interventions.
We present the case of a 34-year-old African male who developed severe HO around his right hip 11 days after a major trauma. Immunohistochemical analyses of resected tissue revealed that several BMPs were expressed in the HO, including highly osteogenic BMP-9.
To the best of our knowledge, this is the first report of local BMP expression, notably BMP-9, in traumatic HO, and suggests that BMP-9, possibly through mrSCs, can contribute to HO formation in soft tissues when a suitable microenvironment is present.
异位骨化（HO）定义为成熟骨在软组织中异常形成，特别是在骨骼肌中。多发创伤患者中 HO 的发病率会影响功能预后，妨碍康复，并因后续的手术干预而增加成本。
我们报告了一名 34 岁的非洲男性病例，他在一次重大创伤后 11 天，其右髋周围出现严重的 HO。对切除组织的免疫组化分析显示，HO 中表达了几种 BMPs，包括高度成骨的 BMP-9。
据我们所知，这是首例报道局部 BMP 表达，特别是 BMP-9，在创伤性 HO 中的表达，这表明 BMP-9 可能通过间充质干细胞（mrSCs），在存在合适的微环境时，有助于软组织中的 HO 形成。
