口服三磷酸腺苷对力量训练男性运动员运动表现、骨骼肌肥大和恢复的影响。
Effects of oral adenosine-5'-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men.
出版信息
Nutr Metab (Lond). 2013 Sep 22;10(1):57. doi: 10.1186/1743-7075-10-57.
BACKGROUND
Currently, there is a lack of studies examining the effects of adenosine-5'-triphosphate (ATP) supplementation utilizing a long-term, periodized resistance-training program (RT) in resistance-trained populations. Therefore, we investigated the effects of 12 weeks of 400 mg per day of oral ATP on muscular adaptations in trained individuals. We also sought to determine the effects of ATP on muscle protein breakdown, cortisol, and performance during an overreaching cycle.
METHODS
The study was a 3-phase randomized, double-blind, and placebo- and diet-controlled intervention. Phase 1 was a periodized resistance-training program. Phase 2 consisted of a two week overreaching cycle in which volume and frequency were increased followed by a 2-week taper (Phase 3). Muscle mass, strength, and power were examined at weeks 0, 4, 8, and 12 to assess the chronic effects of ATP; assessment performance variables also occurred at the end of weeks 9 and 10, corresponding to the mid and endpoints of the overreaching cycle.
RESULTS
There were time (p<0.001), and group x time effects for increased total body strength (+55.3 ± 6.0 kg ATP vs. + 22.4 ± 7.1 kg placebo, p<0.001); increased vertical jump power (+ 796 ± 75 ATP vs. 614 ± 52 watts placebo, p<0.001); and greater ultrasound determined muscle thickness (+4.9 ± 1.0 ATP vs. (2.5 ± 0.6 mm placebo, p<0.02) with ATP supplementation. During the overreaching cycle, there were group x time effects for strength and power, which decreased to a greater extent in the placebo group. Protein breakdown was also lower in the ATP group.
CONCLUSIONS
Our results suggest oral ATP supplementation may enhance muscular adaptations following 12-weeks of resistance training, and prevent decrements in performance following overreaching. No statistically or clinically significant changes in blood chemistry or hematology were observed.
TRIAL REGISTRATION
ClinicalTrials.gov NCT01508338.
背景
目前，缺乏利用长期周期性抗阻训练计划（RT）研究腺苷-5'-三磷酸（ATP）补充对抗阻训练人群的影响的研究。因此，我们研究了每天口服 400mgATP 持续 12 周对训练人群肌肉适应性的影响。我们还试图确定 ATP 对肌肉蛋白分解、皮质醇和超量训练周期中运动表现的影响。
方法
该研究是一项 3 期随机、双盲、安慰剂和饮食对照干预研究。第 1 阶段是周期性抗阻训练计划。第 2 阶段包括为期两周的超量训练周期，其中增加了训练量和训练频率，随后是两周的减量阶段（第 3 阶段）。在第 0、4、8 和 12 周评估肌肉质量、力量和功率，以评估 ATP 的慢性影响；在超量训练周期的中点（第 9 周）和终点（第 10 周）评估运动表现变量。
结果
存在时间（p<0.001）和组间时间的交互作用，用于增加全身力量（ATP 组增加 55.3 ± 6.0kg，安慰剂组增加 22.4 ± 7.1kg，p<0.001）；增加垂直跳跃力量（ATP 组增加 796 ± 75 瓦特，安慰剂组增加 614 ± 52 瓦特，p<0.001）；以及 ATP 补充后超声确定的肌肉厚度增加（ATP 组增加 4.9 ± 1.0mm，安慰剂组增加 2.5 ± 0.6mm，p<0.02）。在超量训练周期中，力量和功率存在组间时间的交互作用，安慰剂组下降幅度更大。ATP 组的蛋白质分解也较低。
结论
我们的结果表明，口服 ATP 补充可能会增强抗阻训练 12 周后的肌肉适应性，并防止超量训练后的运动表现下降。未观察到血液化学或血液学的统计学或临床显著变化。
试验注册
ClinicalTrials.gov NCT01508338。
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