Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Infect Agent Cancer. 2013 Dec 13;8(1):49. doi: 10.1186/1750-9378-8-49.
Akt, better known as protein kinase B (PKB), is a serine/threonine-specific protein kinase which acts as mediator via PI3K/Akt pathway in many biological processes like glucose metabolism, apoptosis, cell differentiation and transcription. Akt1 gene amplification has been implicated in gastric carcinoma while Akt2 amplification has been linked with ovarian, pancreas, breast and stomach tumors. The use of Akt inhibitors as monotherapy or in combination with other anticancer drugs could be useful for combating drug resistance and improving response. Thus, comprehensive understanding of Akt and its linked signaling pathways (PI3K, PKB, mTOR etc.) is necessary to lead to newer drug development and use.
Akt，又称为蛋白激酶 B（PKB），是一种丝氨酸/苏氨酸特异性蛋白激酶，在许多生物学过程中充当介质，如葡萄糖代谢、细胞凋亡、细胞分化和转录。Akt1 基因扩增与胃癌有关，而 Akt2 扩增与卵巢癌、胰腺癌、乳腺癌和胃癌有关。Akt 抑制剂的单独使用或与其他抗癌药物联合使用可能有助于对抗耐药性并提高疗效。因此，全面了解 Akt 及其相关信号通路（PI3K、PKB、mTOR 等）对于开发和使用新型药物是必要的。
