Elmore Susan A, Boyle Michael C, Boyle Molly H, Cora Michelle C, Crabbs Torrie A, Cummings Connie A, Gruebbel Margarita M, Johnson Crystal L, Malarkey David E, McInnes Elizabeth F, Nolte Thomas, Shackelford Cynthia C, Ward Jerrold M
1National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Toxicol Pathol. 2014 Jan;42(1):12-44. doi: 10.1177/0192623313508020. Epub 2013 Dec 13.
The 2013 annual National Toxicology Program (NTP) Satellite Symposium, entitled "Pathology Potpourri," was held in Portland, Oregon, in advance of the Society of Toxicologic Pathology's 32nd annual meeting. The goal of the NTP Symposium is to present current diagnostic pathology or nomenclature issues to the toxicologic pathology community. This article presents summaries of the speakers' presentations, including diagnostic or nomenclature issues that were presented, along with select images that were used for audience voting and discussion. Some lesions and topics covered during the symposium included a caudal tail vertebra duplication in mice; nephroblastematosis in rats; ectopic C cell tumor in a hamster; granular cell aggregates/tumor in the uterus of a hamster; Pneumocystis carinii in the lung of a rat; iatrogenic chronic inflammation in the lungs of control rats; hepatoblastoma arising within an adenoma in a mouse; humoral hypercalcemia of benignancy in a transgenic mouse; acetaminophen-induced hepatotoxicity in rats; electron microscopy images of iatrogenic intraerythrocytic inclusions in transgenic mice; questionable hepatocellular degeneration/cell death/artifact in rats; atypical endometrial hyperplasia in rats; malignant mixed Müllerian tumors/carcinosarcomas in rats; differential diagnoses of proliferative lesions of the intestine of rodents; and finally obstructive nephropathy caused by melamine poisoning in a rat.
2013年国家毒理学计划(NTP)卫星研讨会题为“病理学杂烩”,在毒理病理学会第32届年会之前于俄勒冈州波特兰市举行。NTP研讨会的目标是向毒理病理学领域介绍当前的诊断病理学或命名问题。本文介绍了演讲者的发言摘要,包括所提出的诊断或命名问题,以及用于观众投票和讨论的精选图片。研讨会期间涵盖的一些病变和主题包括小鼠尾椎重复;大鼠肾母细胞瘤;仓鼠异位C细胞瘤;仓鼠子宫颗粒细胞聚集/肿瘤;大鼠肺中的卡氏肺孢子虫;对照大鼠肺中的医源性慢性炎症;小鼠腺瘤内发生的肝母细胞瘤;转基因小鼠的良性体液性高钙血症;大鼠对乙酰氨基酚诱导的肝毒性;转基因小鼠医源性红细胞内包涵体的电子显微镜图像;大鼠可疑的肝细胞变性/细胞死亡/假象;大鼠非典型子宫内膜增生;大鼠恶性混合性苗勒管肿瘤/癌肉瘤;啮齿动物肠道增殖性病变的鉴别诊断;最后是大鼠三聚氰胺中毒引起的梗阻性肾病。