Nam Su-Hyun, Kang Sung-Goo, Song Sang-Wook
Department of Family Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
Department of Family Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea; Health Promotion Center, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
Biomed Res Int. 2017;2017:1989417. doi: 10.1155/2017/1989417. Epub 2017 Feb 9.
. The neutrophil-lymphocyte ratio (NLR) is a significant systemic predictor of cardiovascular disease (CVD). The coronary artery calcium score (CACS) reflects coronary artery calcification and is an independent risk factor for coronary artery stenosis. In the present study, we explored the relationship between the NLR and CACS in terms of subclinical inflammation and coronary artery calcification. . We evaluated males and females who did not have CVD, diabetes, high blood pressure, or high fasting blood sugar levels. We measured white blood cell, neutrophil, lymphocyte counts, fasting blood sugar, total cholesterol, high-density lipoprotein cholesterol, triglycerides (TG), and high-sensitivity C-reactive protein levels in blood samples. We also obtained CACSs using coronary multidetector computed tomography. . Multivariate logistic regression showed that older age was significantly associated with a higher CACS ( < 0.001); males had higher CACSs than females ( < 0.001); and the higher the TG level, the higher the CACS ( = 0.019). The NLR of males, but not females, was significantly associated with the CACS. . An independent association between the NLR and CACS was thus evident in healthy adult males after adjusting for other CVD risk factors. Therefore, the NLR is a significant predictor of potential CVD in male subjects with subclinical atherosclerosis.
中性粒细胞与淋巴细胞比值（NLR）是心血管疾病（CVD）的一个重要全身预测指标。冠状动脉钙化积分（CACS）反映冠状动脉钙化情况，是冠状动脉狭窄的一个独立危险因素。在本研究中，我们从亚临床炎症和冠状动脉钙化方面探讨了NLR与CACS之间的关系。我们评估了无CVD、糖尿病、高血压或空腹血糖水平升高的男性和女性。我们检测了血样中的白细胞、中性粒细胞、淋巴细胞计数、空腹血糖、总胆固醇、高密度脂蛋白胆固醇、甘油三酯（TG）和高敏C反应蛋白水平。我们还使用冠状动脉多排计算机断层扫描获得了CACS。多变量逻辑回归显示，年龄较大与较高的CACS显著相关（<0.001）；男性的CACS高于女性（<0.001）；TG水平越高，CACS越高（=0.019）。男性而非女性的NLR与CACS显著相关。在调整其他CVD危险因素后，健康成年男性中NLR与CACS之间的独立关联因此很明显。因此，NLR是亚临床动脉粥样硬化男性受试者潜在CVD的一个重要预测指标。
