Liu Yan-Ping, Chen Gang, Wang Hai-Feng, Zhang Xiao-Li, Pei Yue-Hu
a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , 110016 , China.
J Asian Nat Prod Res. 2014;16(3):281-4. doi: 10.1080/10286020.2013.867851. Epub 2013 Dec 18.
Our current natural product program researches the second metabolites of a fungus Penicilliumcrustosum YN-HT-15 isolated from the red soil (Yunnan Province, China), to discover potential antitumor chemical entities. Two new compounds were isolated from the ethyl acetate extract of the fermentation broth of the fungus, and their structures were characterized as 1-(2',4'-dihydroxy-5'-methyl-3'-methylsulfanylmethyl-phenyl)-ethanone and R-3-(3'-acetyl-2',6'-dihydroxy-5'-methylphenyl)-2-methyl-propionic acid methyl ester on the basis of spectroscopic data.
我们目前的天然产物项目研究了从红壤（中国云南省）中分离出的一种真菌—— crustosum YN-HT-15 的次生代谢产物，以发现潜在的抗肿瘤化学实体。从该真菌发酵液的乙酸乙酯提取物中分离出两种新化合物，根据光谱数据，它们的结构被鉴定为 1-(2',4'-二羟基-5'-甲基-3'-甲基硫烷基甲基-苯基)-乙酮和 R-3-(3'-乙酰基-2',6'-二羟基-5'-甲基苯基)-2-甲基-丙酸甲酯。
