基因-饮食相互作用与体重减轻。
Gene-diet interaction and weight loss.
作者信息
Qi Lu
机构信息
aDepartment of Nutrition, Harvard School of Public Health bChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Curr Opin Lipidol. 2014 Feb;25(1):27-34. doi: 10.1097/MOL.0000000000000037.
PURPOSE OF REVIEW
The purpose of this review is to summarize recent advances in investigations of dietary factors, genetic factors, and their interactive effects on obesity and weight loss.
RECENT FINDINGS
Even with a tremendous body of research conducted, controversy still abounds regarding the relative effectiveness of various weight-loss diets. Recent advances in genome-wide association studies have made great strides in unraveling the genetic basis of regulation of body weight. In prospective cohorts, reproducible evidence is emerging to show interactions between genetic factors and dietary factors such as sugar-sweetened beverage on obesity. In randomized clinical trials, individuals' genotypes have also been found to modify diet interventions on weight loss, weight maintenance, and changes in related metabolic traits such as lipids, insulin resistance, and blood pressure. However, replication, functional exploration, and translation of the findings into personalized diet interventions remain the chief challenges.
SUMMARY
Preliminary but promising data have emerged to lend support to gene-diet interaction in determining weight loss and maintenance; and studies in the area hold great promise to inform future personalized diet interventions on the reduction of obesity and related health problems.
综述目的
本综述旨在总结饮食因素、遗传因素及其对肥胖和体重减轻的交互作用研究的最新进展。
最新发现
尽管已经开展了大量研究，但关于各种减肥饮食的相对有效性仍存在诸多争议。全基因组关联研究的最新进展在揭示体重调节的遗传基础方面取得了巨大进展。在前瞻性队列研究中，越来越多的可重复证据表明遗传因素与饮食因素（如含糖饮料）在肥胖问题上存在相互作用。在随机临床试验中，也发现个体基因型会影响减肥、体重维持以及相关代谢特征（如血脂、胰岛素抵抗和血压）的饮食干预效果。然而，研究结果的重复验证、功能探索以及将其转化为个性化饮食干预仍然是主要挑战。
总结
初步但有前景的数据支持了基因 - 饮食相互作用在决定体重减轻和维持方面的作用；该领域的研究有望为未来减少肥胖及相关健康问题的个性化饮食干预提供依据。
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