School of Health Sciences, Federal University of Grande Dourados, Caixa Postal-322, Dourados, MS, Brazil.
Mato Grosso do Sul State University, Caixa Postal-351, Dourados, MS, Brazil.
Evid Based Complement Alternat Med. 2013;2013:414821. doi: 10.1155/2013/414821. Epub 2013 Nov 17.
Jacaranda decurrens subsp. symmetrifoliolata Farias & Proença (Bignoniaceae) is a species traditionally used for the treatment of inflammatory and infectious diseases. Previous findings from our group reported scientifically that J. decurrens has anti-inflammatory efficacy. However, more toxicological studies are needed to support and ensure its safe use. The present study was carried out to evaluate the toxic effects of a prolonged treatment with hydroethanolic root extract of J. decurrens (EJD) on hematological, biochemical, and reproductive parameters in adult male rats. The animals received by oral gavage 0; 250; 500; or 1000 mg/kg body weight of EJD for 28 days. After the treatment, biochemical, hematological, histopathological, and reproductive parameters were analyzed. The EJD treatment did not cause adverse effects on body weight gain, feed and water consumption, hematological and biochemical profiles, or histopathological analysis of liver and kidney. Similarly, there were no statistically significant differences in reproductive parameters, such as sperm production, number of sperm in the epididymis, and sperm morphology. These results demonstrate the absence of subacute toxicity as a result of the oral treatment with EJD for 28 days in adult male rats. However, other studies should be performed to evaluate the total safety of this plant.
尖瓣蓝（Bignoniaceae）是一种传统的用于治疗炎症和传染病的物种。我们小组之前的研究结果从科学上表明尖瓣蓝具有抗炎功效。然而，需要更多的毒理学研究来支持并确保其安全使用。本研究旨在评估长期口服尖瓣蓝（EJD）水醇根提取物对成年雄性大鼠血液学、生化和生殖参数的毒性作用。动物通过口服灌胃接受 0；250；500；或 1000 mg/kg 体重的 EJD，连续 28 天。治疗后，分析生化、血液学、组织病理学和生殖参数。EJD 处理未对体重增加、饲料和水的消耗、血液学和生化学特征或肝和肾的组织病理学分析产生不良影响。同样，精子产生、附睾精子数量和精子形态等生殖参数也没有统计学上的显著差异。这些结果表明，在成年雄性大鼠中口服 EJD 28 天不会导致亚急性毒性。然而，应该进行其他研究来评估这种植物的整体安全性。
