Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Division of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Evid Based Complement Alternat Med. 2013;2013:568074. doi: 10.1155/2013/568074. Epub 2013 Nov 18.
We have performed a broad-ranging analysis of the adjuvant effect of a Kampo medicine, juzentaihoto (JTT), on influenza vaccination in a multicenter randomized controlled trial. In this study, the enhancing effect of JTT on antibody titer after influenza vaccination was studied for 28 weeks in elderly people who were in the high-risk group for influenza infection. In total, 91 subjects over 65 years old were recruited from four long-term-care facilities located in Chiba, Gunma, and Toyama prefectures in Japan. Participants were randomly assigned to the JTT and the control groups. Blood samples were taken at 4 weeks before vaccination, at the time of vaccination, and then at 4, 8, 12, and 24 weeks after vaccination. The hemagglutination inhibition (HI) titers against A/California/7/2009 (H1N1), A/Victoria/210/2009 (H3N2), and B/Brisbane/60/2008 were then manually measured. A significant increase in HI titer against H3N2 was observed at week 8 after vaccination in the JTT group compared with the control group (P = 0.0229), and the HI titer of the JTT group significantly increased from 4 to 24 weeks (P = 0.0468), compared with the control group. In conclusion, our results indicated that JTT increased and prolonged antibody production against A/Victoria/210/2009 (H3N2), in particular, after influenza vaccination.
我们在一项多中心随机对照试验中对汉方药（JTTH）对流感疫苗的佐剂效应进行了广泛分析。在这项研究中，研究了 JTTH 对感染流感高风险的老年人接种流感疫苗后 28 周内抗体滴度的增强作用。共有 91 名 65 岁以上的参与者从日本千叶县、群马县和富山县的四个长期护理机构中招募。参与者被随机分配到 JTTH 和对照组。在接种疫苗前 4 周、接种时以及接种后 4、8、12 和 24 周采集血样。然后手动测量针对 A/California/7/2009（H1N1）、A/Victoria/210/2009（H3N2）和 B/Brisbane/60/2008 的血凝抑制（HI）滴度。与对照组相比，接种后 8 周时 JTTH 组针对 H3N2 的 HI 滴度显著升高（P = 0.0229），与对照组相比，JTTH 组的 HI 滴度从 4 周到 24 周显著升高（P = 0.0468）。总之，我们的结果表明，JTTH 增加并延长了针对 A/Victoria/210/2009（H3N2）的抗体产生，特别是在流感疫苗接种后。
