Sasabuchi Yusuke, Matsui Hiroki, Lefor Alan Kawarai, Jo Taisuke, Michihata Nobuaki, Fushimi Kiyohide, Yasunaga Hideo
Data Science Center, Jichi Medical University, Tochigi, Japan.
Department of Clinical Epidemiology and Health Economics, The University of Tokyo, Tokyo, Japan.
Evid Based Complement Alternat Med. 2018 Apr 29;2018:8620198. doi: 10.1155/2018/8620198. eCollection 2018.
Infectious complications after hip fracture surgery are common in the elderly. Although experimental studies have suggested that kampo medicine, Hochu-ekki-to and Juzen-taiho-to, can prevent infectious complications, only a few small clinical studies have been published to date.
The aim of the present study is to investigate the impact of Hochu-ekki-to or Juzen-taiho-to on postoperative infectious complications in patients undergoing surgery for hip fracture.
In this retrospective cohort study using a nationwide inpatient database in Japan, we performed propensity score matching to compare patients who did or did not receive kampo medicine after surgery for hip fracture.
A nationwide inpatient database.
Patients who did or did not receive kampo medicine after surgery for hip fracture.
Kampo medicine after surgery for hip fracture.
Infectious complications.
The proportions of postoperative infectious complications were not significantly different between the 424 propensity-matched pairs with and without kampo medicine (11 versus 8, = 0.644).
The present study suggests that Hochu-ekki-to or Juzen-taiho-to postoperatively is not associated with decreased occurrence of infectious complications in patients who underwent surgery for hip fracture.
髋部骨折手术后的感染并发症在老年人中很常见。尽管实验研究表明，汉方药物，如补中益气汤和十全大补汤，可以预防感染并发症，但迄今为止，仅有少数小型临床研究发表。
本研究的目的是调查补中益气汤或十全大补汤对髋部骨折手术患者术后感染并发症的影响。
在这项使用日本全国住院患者数据库的回顾性队列研究中，我们进行了倾向评分匹配，以比较髋部骨折手术后接受或未接受汉方药物治疗的患者。
全国住院患者数据库。
髋部骨折手术后接受或未接受汉方药物治疗的患者。
髋部骨折手术后使用汉方药物。
感染并发症。
在424对倾向评分匹配的接受和未接受汉方药物治疗的患者中，术后感染并发症的比例没有显著差异（分别为11例和8例，P = 0.644）。
本研究表明，髋部骨折手术后使用补中益气汤或十全大补汤与感染并发症发生率降低无关。
