Department of Chest Surgery; Kunming General Hospital of Chengdu Military Region, Kunming, Yunnan Province, China.
PLoS One. 2012;7(9):e43412. doi: 10.1371/journal.pone.0043412. Epub 2012 Sep 11.
The purpose of this study is to explore the relationship between the interactions of CYP2C19 gene polymorphisms and several environmental factors and oesophageal squamous cell carcinoma (OSCC).
In a case-control study of OSCC patients (n = 350) and healthy controls (n = 350), we investigated the roles of polymorphism in the CYP2C19 gene by the use of polymerase chain reaction--restriction fragment length polymorphism (PCR - RFLP) analysis.
The CYP2C19()3 AG+AA genotype was significantly more prevalent in OSCC patients (10.0% versus 3.43%; P<0.01). Multiple logistic regression analysis showed drinking (OR: 5.603, 95% CI: 3.431-11.112; P = 0.005) and smoking (OR: 4.341, 95% CI: 3.425-10.241; P = 0.001) was the independent risk factor of OSCC respectively, and there were significant interaction between CYP2C19()3 and drinking (OR: 8.747, 95% CI: 6.321-18.122; P = 0.009).
The CYP2C19(*)3 polymorphism and OSCC were synergistically and significantly associated in Chinese Han patients.
本研究旨在探讨 CYP2C19 基因多态性与多种环境因素相互作用与食管鳞状细胞癌（OSCC）的关系。
采用病例对照研究，对 350 例 OSCC 患者和 350 例健康对照者进行 CYP2C19 基因多态性分析，采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析。
CYP2C19（）3 AG+AA 基因型在 OSCC 患者中明显更为常见（10.0%比 3.43%；P<0.01）。多因素 logistic 回归分析显示，饮酒（OR：5.603，95%CI：3.431-11.112；P=0.005）和吸烟（OR：4.341，95%CI：3.425-10.241；P=0.001）是 OSCC 的独立危险因素，且 CYP2C19（）3 与饮酒之间存在显著的交互作用（OR：8.747，95%CI：6.321-18.122；P=0.009）。
CYP2C19（*）3 多态性与 OSCC 在汉族患者中具有协同显著相关性。
