血管紧张素转换酶基因多态性与老年糖尿病高血压及血脂水平的相关性研究。
Association study of angiotensin converting enzyme gene polymorphism with elderly diabetic hypertension and lipids levels.
机构信息
The cadre ward of General Hospital of the Air Force PLA, No, 30, Fucheng Road, Haidian District, Beijing 100142, China.
出版信息
Lipids Health Dis. 2013 Dec 19;12:187. doi: 10.1186/1476-511X-12-187.
OBJECTIVE
To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and diabetic essential hypertension in elderly population.
METHODS
Polymerase chain reaction (PCR) technique was used in 260 elderly normal control patients, 205 elderly hypertensive patients and 138 elderly diabetic hypertensive patients to detect the I/D polymorphism in ACE gene.
RESULTS
DD genotype frequency (0.352) and D allele frequency (0.543) in elderly hypertensive patients were higher than those in the normal control patients. DD genotype (0.421) and D allele frequency (0.579) in elderly diabetic hypertensive patients were significantly higher than those in the control patients (0.133 and 0.250). The differences of DD genotype and D allele frequency between the elderly hypertensive patients and the elderly diabetic hypertensive patients were not significant (P > 0.05).
CONCLUSION
ACE gene deletion is a risk factor for hypertension but is not a risk factor for diabetes in elderly population.
目的
探讨血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性与老年人群糖尿病性原发性高血压的关系。
方法
采用聚合酶链反应（PCR）技术检测 260 例老年正常对照组、205 例老年高血压组和 138 例老年糖尿病高血压组 ACE 基因 I/D 多态性。
结果
老年高血压组 DD 基因型频率（0.352）和 D 等位基因频率（0.543）高于正常对照组。老年糖尿病高血压组 DD 基因型（0.421）和 D 等位基因频率（0.579）明显高于对照组（0.133 和 0.250）。老年高血压组与老年糖尿病高血压组的 DD 基因型和 D 等位基因频率差异无统计学意义（P>0.05）。
结论
ACE 基因缺失是老年人群高血压的危险因素，但不是糖尿病的危险因素。
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