• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Hydrogen tunneling in enzymes and biomimetic models.

作者信息

Layfield Joshua P, Hammes-Schiffer Sharon

机构信息

Department of Chemistry, University of Illinois at Urbana-Champaign , 600 South Mathews Avenue, Urbana, Illinois 61801, United States.

出版信息

Chem Rev. 2014 Apr 9;114(7):3466-94. doi: 10.1021/cr400400p. Epub 2013 Dec 20.

DOI:10.1021/cr400400p
PMID:24359189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3981923/
Abstract
摘要

相似文献

1
Hydrogen tunneling in enzymes and biomimetic models.酶及仿生模型中的氢隧穿效应
Chem Rev. 2014 Apr 9;114(7):3466-94. doi: 10.1021/cr400400p. Epub 2013 Dec 20.
2
Structural bases of hydrogen tunneling in enzymes: progress and puzzles.酶中氢隧穿的结构基础：进展与谜题
Curr Opin Struct Biol. 2004 Dec;14(6):648-55. doi: 10.1016/j.sbi.2004.10.008.
3
Hydrogen tunneling in enzyme catalysis.酶催化中的氢隧穿效应。
Methods Enzymol. 1995;249:373-97. doi: 10.1016/0076-6879(95)49042-6.
4
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.环境耦合氢隧穿。将催化与动力学联系起来。
Eur J Biochem. 2002 Jul;269(13):3113-21. doi: 10.1046/j.1432-1033.2002.03022.x.
5
Importance of protein dynamics during enzymatic C-H bond cleavage catalysis.酶促 C-H 键断裂催化过程中蛋白质动力学的重要性。
Biochemistry. 2013 Mar 26;52(12):2068-77. doi: 10.1021/bi301504m. Epub 2013 Feb 12.
6
Enzymes: by chance, or by design?酶：偶然形成，还是设计而成？
Nature. 2004 Sep 23;431(7007):396-7. doi: 10.1038/431396a.
7
Hydride transfer in liver alcohol dehydrogenase: quantum dynamics, kinetic isotope effects, and role of enzyme motion.肝脏乙醇脱氢酶中的氢化物转移：量子动力学、动力学同位素效应及酶运动的作用
J Am Chem Soc. 2001 Nov 14;123(45):11262-72. doi: 10.1021/ja011384b.
8
A qualitative quantum rate model for hydrogen transfer in soybean lipoxygenase.大豆脂氧合酶氢转移的定性量子速率模型。
J Chem Phys. 2017 Sep 21;147(11):114108. doi: 10.1063/1.4998941.
9
Simulations of the large kinetic isotope effect and the temperature dependence of the hydrogen atom transfer in lipoxygenase.脂氧合酶中氢原子转移的大动力学同位素效应及温度依赖性的模拟
J Am Chem Soc. 2004 Mar 10;126(9):2820-8. doi: 10.1021/ja037233l.
10
Boundary conditions for the Swain-Schaad relationship as a criterion for hydrogen tunneling.作为氢隧穿判据的斯温-沙德关系的边界条件。
J Am Chem Soc. 2002 Apr 17;124(15):3858-64. doi: 10.1021/ja016909e.

引用本文的文献

1
The Quantum Paradox in Pharmaceutical Science: Understanding Without Comprehending-A Centennial Reflection.药学中的量子悖论：不求甚解的理解——百年反思
Int J Mol Sci. 2025 May 13;26(10):4658. doi: 10.3390/ijms26104658.
2
A Foundational Shift in Models for Enzyme Function.酶功能模型的根本性转变。
J Am Chem Soc. 2025 May 7;147(18):14884-14904. doi: 10.1021/jacs.5c02388. Epub 2025 Apr 25.
3
Structural Effects on the Hydride-Tunneling Kinetic Isotope Effects of NADH/NAD Model Reactions: Relating to the Donor-Acceptor Distances.

本文引用的文献

1
An Integrated Path Integral and Free-Energy Perturbation-Umbrella Sampling Method for Computing Kinetic Isotope Effects of Chemical Reactions in Solution and in Enzymes.一种用于计算溶液和酶中化学反应动力学同位素效应的综合路径积分与自由能微扰-伞形抽样方法。
J Chem Theory Comput. 2007 May;3(3):949-60. doi: 10.1021/ct600371k.
2
Isotope Effects on the Nonequilibrium Dynamics of Ultrafast Photoinduced Proton-Coupled Electron Transfer Reactions in Solution.同位素对溶液中超快光致质子耦合电子转移反应非平衡动力学的影响。
J Phys Chem Lett. 2011 Jan 6;2(1):36-40. doi: 10.1021/jz101532g. Epub 2010 Dec 17.
3
Theoretical Design of Molecular Electrocatalysts with Flexible Pendant Amines for Hydrogen Production and Oxidation.
NADH/NAD模型反应中氢化物隧穿动力学同位素效应的结构影响：与供体-受体距离的关系
J Org Chem. 2025 Feb 28;90(8):3110-3115. doi: 10.1021/acs.joc.4c03080. Epub 2025 Feb 13.
4
Reactivity of a heterobinuclear heme-peroxo-Cu complex with -substituted catechols shows a p -dependent change in mechanism.一种异双核血红素-过氧-铜配合物与对位取代儿茶酚的反应性显示出反应机理随p的依赖性变化。
Chem Sci. 2024 Dec 30;16(5):2402-2412. doi: 10.1039/d4sc05623j. eCollection 2025 Jan 29.
5
Nuclear Quantum Effects in Quantum Mechanical/Molecular Mechanical Free Energy Simulations of Ribonucleotide Reductase.核糖核苷酸还原酶量子力学/分子力学自由能模拟中的核量子效应
J Am Chem Soc. 2024 Dec 4;146(48):33258-33264. doi: 10.1021/jacs.4c13955. Epub 2024 Nov 20.
6
Proton-Coupled Electron Transfer and Hydrogen Tunneling in Olive Oil Phenol Reactions.橄榄酚反应中的质子耦合电子转移和氢隧穿。
Int J Mol Sci. 2024 Jun 7;25(12):6341. doi: 10.3390/ijms25126341.
7
Thermoswitchable catalysis to inhibit and promote plastic flow in vitrimers.热开关催化抑制和促进 Vitrimers 中的塑性流动。
Chem Sci. 2024 Mar 26;15(19):7061-7071. doi: 10.1039/d4sc00417e. eCollection 2024 May 15.
8
Study of the Effects of Remote Heavy Group Vibrations on the Temperature Dependence of Hydride Kinetic Isotope Effects of the NADH/NAD Model Reactions.远程重基团振动对NADH/NAD模型反应中氢化物动力学同位素效应温度依赖性的影响研究
ACS Omega. 2024 Apr 24;9(18):20593-20600. doi: 10.1021/acsomega.4c02383. eCollection 2024 May 7.
9
Structural Effects on the Temperature Dependence of Hydride Kinetic Isotope Effects of the NADH/NAD Model Reactions in Acetonitrile: Charge-Transfer Complex Tightness Is a Key.乙腈中NADH/NAD模型反应的氢化物动力学同位素效应温度依赖性的结构效应：电荷转移络合物的紧密性是关键。
J Org Chem. 2024 Mar 1;89(5):3184-3193. doi: 10.1021/acs.joc.3c02562. Epub 2024 Feb 16.
10
Probing Nonadiabaticity of Proton-Coupled Electron Transfer in Ribonucleotide Reductase.探究核酶还原酶中质子耦合电子转移的非绝热性。
J Phys Chem Lett. 2024 Feb 15;15(6):1686-1693. doi: 10.1021/acs.jpclett.3c03552. Epub 2024 Feb 5.
用于析氢和氧化反应的含柔性侧链胺的分子电催化剂的理论设计
J Phys Chem Lett. 2013 Feb 7;4(3):542-6. doi: 10.1021/jz3020277. Epub 2013 Jan 29.
4
The EVB as a quantitative tool for formulating simulations and analyzing biological and chemical reactions.作为一种用于制定模拟以及分析生物和化学反应的定量工具的EVB。
Faraday Discuss. 2010;145:71-106. doi: 10.1039/B907354J.
5
Hydrogen tunneling links protein dynamics to enzyme catalysis.氢隧穿将蛋白质动力学与酶催化联系起来。
Annu Rev Biochem. 2013;82:471-96. doi: 10.1146/annurev-biochem-051710-133623.
6
Reversible, long-range radical transfer in E. coli class Ia ribonucleotide reductase.大肠杆菌Ⅰa 核糖核苷酸还原酶中可逆的长程自由基转移。
Acc Chem Res. 2013 Nov 19;46(11):2524-35. doi: 10.1021/ar4000407. Epub 2013 Jun 4.
7
Direct simulation of proton-coupled electron transfer across multiple regimes.质子耦合电子转移跨越多个区域的直接模拟。
J Chem Phys. 2013 Apr 7;138(13):134109. doi: 10.1063/1.4797462.
8
Long Range Proton-Coupled Electron Transfer Reactions of Bis(imidazole) Iron Tetraphenylporphyrins Linked to Benzoates.与苯甲酸酯相连的双（咪唑）铁四苯基卟啉的远程质子耦合电子转移反应
J Phys Chem Lett. 2013 Feb 7;4(3):519-523. doi: 10.1021/jz400029w. Epub 2013 Jan 14.
9
pH-dependent reduction potentials and proton-coupled electron transfer mechanisms in hydrogen-producing nickel molecular electrocatalysts.产氢镍分子电催化剂中 pH 值依赖的还原电势和质子耦合电子转移机制。
Inorg Chem. 2013 Apr 1;52(7):3643-52. doi: 10.1021/ic302056j. Epub 2013 Mar 11.
10
Importance of protein dynamics during enzymatic C-H bond cleavage catalysis.酶促 C-H 键断裂催化过程中蛋白质动力学的重要性。
Biochemistry. 2013 Mar 26;52(12):2068-77. doi: 10.1021/bi301504m. Epub 2013 Feb 12.