酶促 C-H 键断裂催化过程中蛋白质动力学的重要性。
Importance of protein dynamics during enzymatic C-H bond cleavage catalysis.
机构信息
Department of Chemistry, Department of Molecular and Cell Biology, and California Institute for Quantitative Biosciences (QB3), University of California , Berkeley, California 94720-3220, United States.
出版信息
Biochemistry. 2013 Mar 26;52(12):2068-77. doi: 10.1021/bi301504m. Epub 2013 Feb 12.
Abstract
Quantum tunneling and protein dynamics have emerged as important components of enzyme function. This review focuses on soybean lipoxygenase-1, to illustrate how the properties of enzymatic C-H bond activation link protein motions to the fundamental bond making-breaking processes.
摘要
量子隧穿和蛋白质动力学已成为酶功能的重要组成部分。本综述以大豆脂氧合酶-1 为例，来说明酶 C-H 键活化特性如何将蛋白质运动与基本的成键-断键过程联系起来。
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