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Immunotherapy for advanced melanoma: fulfilling the promise.晚期黑色素瘤的免疫治疗：兑现承诺。
Cancer Treat Rev. 2013 Dec;39(8):879-85. doi: 10.1016/j.ctrv.2013.04.006. Epub 2013 May 29.
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Common cancer risk and statins: a population-based case-control study in a Chinese population.常见癌症风险与他汀类药物：一项基于人群的中国人群病例对照研究。
Expert Opin Drug Saf. 2013 Jan;12(1):19-27. doi: 10.1517/14740338.2013.744392. Epub 2012 Dec 1.
3
Statins and the risk of cancer after heart transplantation.他汀类药物与心脏移植后癌症风险。
Circulation. 2012 Jul 24;126(4):440-7. doi: 10.1161/CIRCULATIONAHA.111.081059. Epub 2012 Jul 3.
4
Increased incidence of Merkel cell carcinoma among younger statin users.在较年轻的他汀类药物使用者中， Merkel 细胞癌的发病率增加。
Cancer Epidemiol. 2012 Oct;36(5):421-4. doi: 10.1016/j.canep.2012.05.006. Epub 2012 Jun 7.
5
Statins in dermatology: is nonmelanoma skin cancer the dark side of the moon?
Int J Dermatol. 2013 Jul;52(7):899-900. doi: 10.1111/j.1365-4632.2011.05067.x. Epub 2012 Apr 18.
6
Prospective analysis of association between use of statins and melanoma risk in the Women's Health Initiative.前瞻性分析他汀类药物的使用与妇女健康倡议中黑色素瘤风险之间的关系。
Cancer. 2012 Oct 15;118(20):5124-31. doi: 10.1002/cncr.27497. Epub 2012 Mar 20.
7
Targeting tumor cell metabolism with statins.他汀类药物靶向肿瘤细胞代谢。
Oncogene. 2012 Nov 29;31(48):4967-78. doi: 10.1038/onc.2012.6. Epub 2012 Feb 6.
8
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials.Cochrane 协作网评估随机试验偏倚风险的工具。
BMJ. 2011 Oct 18;343:d5928. doi: 10.1136/bmj.d5928.
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Fluvastatin enhances sorafenib cytotoxicity in melanoma cells via modulation of AKT and JNK signaling pathways.氟伐他汀通过调节 AKT 和 JNK 信号通路增强黑素瘤细胞索拉非尼的细胞毒性。
Anticancer Res. 2011 Oct;31(10):3259-65.
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Exposure to statins and risk of common cancers: a series of nested case-control studies.暴露于他汀类药物与常见癌症风险：一系列嵌套病例对照研究。
BMC Cancer. 2011 Sep 26;11:409. doi: 10.1186/1471-2407-11-409.

他汀类药物的使用与降低皮肤癌风险无关：一项荟萃分析。

Statin use is not associated with reduced risk of skin cancer: a meta-analysis.

机构信息

Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China.

出版信息

Br J Cancer. 2014 Feb 4;110(3):802-7. doi: 10.1038/bjc.2013.762. Epub 2013 Dec 24.

DOI:10.1038/bjc.2013.762
PMID:24366301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3915126/
Abstract

BACKGROUND

There is contradictory evidence about the association between statin and skin cancer.

METHODS

Literature search in PubMed and Web of Science was undertaken up to June 2013. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated.

RESULT

A total of 21 articles with 29 studies were identified. No association was found between statin and skin cancer among neither melanoma (RR, 0.94; 95% CI, 0.85-1.04) nor non-melanoma skin cancer (RR, 1.03; 95% CI, 0.90-1.19).

CONCLUSION

Our meta-analysis does not support a potential role of statin use in the prevention of skin cancer.

摘要

背景

他汀类药物与皮肤癌之间的关联存在相互矛盾的证据。

方法

对截至 2013 年 6 月在 PubMed 和 Web of Science 进行的文献检索进行了研究。计算了汇总的相对风险 (RR)估计值和 95%置信区间 (CI)。

结果

共确定了 21 篇文章和 29 项研究。他汀类药物与黑色素瘤（RR，0.94；95%CI，0.85-1.04）或非黑色素瘤皮肤癌（RR，1.03；95%CI，0.90-1.19）之间均无关联。

结论

我们的荟萃分析不支持他汀类药物使用在预防皮肤癌方面的潜在作用。