Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China.
Br J Cancer. 2014 Feb 4;110(3):802-7. doi: 10.1038/bjc.2013.762. Epub 2013 Dec 24.
There is contradictory evidence about the association between statin and skin cancer.
Literature search in PubMed and Web of Science was undertaken up to June 2013. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated.
A total of 21 articles with 29 studies were identified. No association was found between statin and skin cancer among neither melanoma (RR, 0.94; 95% CI, 0.85-1.04) nor non-melanoma skin cancer (RR, 1.03; 95% CI, 0.90-1.19).
Our meta-analysis does not support a potential role of statin use in the prevention of skin cancer.
他汀类药物与皮肤癌之间的关联存在相互矛盾的证据。
对截至 2013 年 6 月在 PubMed 和 Web of Science 进行的文献检索进行了研究。计算了汇总的相对风险 (RR)估计值和 95%置信区间 (CI)。
共确定了 21 篇文章和 29 项研究。他汀类药物与黑色素瘤(RR,0.94;95%CI,0.85-1.04)或非黑色素瘤皮肤癌(RR,1.03;95%CI,0.90-1.19)之间均无关联。
我们的荟萃分析不支持他汀类药物使用在预防皮肤癌方面的潜在作用。