Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Evid Based Complement Alternat Med. 2013;2013:707285. doi: 10.1155/2013/707285. Epub 2013 Nov 28.
The fruit of Physalis peruviana L. (PPL) has been traditionally used as antispasmodic, diuretic, antiseptic, sedative, and analgesic all over the world. We aimed to perform qualitative content analysis of the fruits of PPL and to clarify the in vitro genotoxicity and in vivo acute and subchronic toxicity of the fruit. Lyophilized fruit juice does not induce genetic damage. In the acute toxicity studies, LD50 value of the fruit was found to be more than 5000 mg kg(-1) for both sexes. According to the subchronic toxicity studies, hepatic, renal, and hematological toxic effects were not induced in both sexes. Plasma troponin I (only in the group treated with 5000 mg kg(-1) of lyophilized fruit juice) and troponin T levels were significantly increased in male groups treated with lyophilized fruit juice compared to the control group. Furthermore, potassium level was significantly increased in the male group treated with 5000 mg kg(-1) of lyophilized fruit juice. These findings were considered to indicate the myocardial damage particularly in the male group treated with 5000 mg kg(-1) of lyophilized fruit juice. In conclusion, lyophilized fruit juice of PPL is shown to induce cardiac toxicity only at high doses and in male gender.
灯笼果的果实（PPL）在世界各地一直被用作抗痉挛、利尿、防腐剂、镇静剂和镇痛药。我们旨在对灯笼果的果实进行定性内容分析，并阐明其体外遗传毒性以及体内急性和亚慢性毒性。冻干果汁不会引起遗传损伤。在急性毒性研究中，发现该果实对雌雄两性的 LD50 值均大于 5000mg/kg。根据亚慢性毒性研究，雌雄两性均未引起肝、肾和血液毒性作用。与对照组相比，用冻干果汁处理的雄性组的血浆肌钙蛋白 I（仅在接受 5000mg/kg 冻干果汁处理的组中）和肌钙蛋白 T 水平显著升高。此外，用 5000mg/kg 冻干果汁处理的雄性组的钾水平显著升高。这些发现被认为表明心肌损伤，特别是在接受 5000mg/kg 冻干果汁处理的雄性组中。总之，冻干的灯笼果果汁仅在高剂量和雄性中显示出心脏毒性。
