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Obesity hypoventilation syndrome: mechanisms and management.肥胖低通气综合征:发病机制与治疗。
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夜间脉搏血氧饱和度监测在识别病态肥胖和非肥胖患者阻塞性睡眠呼吸暂停综合征中的作用。

The role of overnight pulse-oximetry in recognition of obstructive sleep apnea syndrome in morbidly obese and non obese patients.

作者信息

Dumitrache-Rujinski Stefan, Calcaianu George, Zaharia Dragos, Toma Claudia Lucia, Bogdan Miron

机构信息

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; "Marius Nasta" Institute of Pneumology, Bucharest, Romania.

"Marius Nasta" Institute of Pneumology, Bucharest, Romania.

出版信息

Maedica (Bucur). 2013 Sep;8(3):237-42.

PMID:24371491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3869111/
Abstract

MATERIAL AND METHODS

We prospectively evaluated 199 individuals with high pre-test clinical suspicion of OSAS. Of these, 123 patients were morbidly obese (Group A) and 76 were non-obese (Group B). We performed six channel cardio-respiratory polygraphy and assessed the correlation between the Desaturation Index (DI) and the Apnea Hypopnea Index (AHI) for both groups.

RESULTS

In group A: 116 patients (94.3%) were diagnosed with OSAS (AHI>5/hour); mean age: 59.4±10.9 years; mean BMI: 44.8±4.9 kg/m(2). The mean DI was 47.2±27.6/hour and the mean AHI: 46.5±27.6/hour. Mean average SaO2 was 88.5±6.3 %. In group B, 65 patients (85.52%) were diagnosed with SAS; mean age: 51.2 ± 12.7 years; mean BMI: 27.24±2.2 kg/m(2).The mean DI was 23.12 ± 18.35/hour and the mean AHI: 28.8 ± 18.5/hour. Mean average SaO2 was 93.7±2.07 %.A significant positive correlation (correlation index rA = 0.863 and rB= 0.877) was found between DI and AHI in both groups (p<0.001).

CONCLUSION

Assessment of the Desaturation Index by nocturnal pulse-oximetry maintains its utility as a screening method for OSAS in both obese and non-obese patients with high clinical pre-test suspicion, despite the fact that the basal nocturnal saturation was found to be lower in group A.

摘要

材料与方法

我们前瞻性地评估了199例临床预测试高度怀疑患有阻塞性睡眠呼吸暂停低通气综合征(OSAS)的个体。其中,123例患者为病态肥胖(A组),76例为非肥胖患者(B组)。我们进行了六通道心肺多导睡眠监测,并评估了两组的血氧饱和度下降指数(DI)和呼吸暂停低通气指数(AHI)之间的相关性。

结果

A组:116例患者(94.3%)被诊断为OSAS(AHI>5次/小时);平均年龄:59.4±10.9岁;平均体重指数(BMI):44.8±4.9kg/m²。平均DI为47.2±27.6次/小时,平均AHI为46.5±27.6次/小时。平均夜间血氧饱和度(SaO₂)为88.5±6.3%。B组中,65例患者(85.52%)被诊断为睡眠呼吸暂停综合征(SAS);平均年龄:51.2±12.7岁;平均BMI:27.24±2.2kg/m²。平均DI为23.12±18.35次/小时,平均AHI为28.8±18.5次/小时。平均夜间SaO₂为93.7±2.07%。两组的DI和AHI之间均发现显著正相关(相关指数rA = 0.863,rB = 0.877)(p<0.001)。

结论

尽管A组夜间基础饱和度较低,但通过夜间脉搏血氧饱和度测定评估血氧饱和度下降指数,对于临床预测试高度怀疑的肥胖和非肥胖患者,仍可作为OSAS的筛查方法。