Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou, Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
Adv Mater. 2014 Mar 26;26(12):1886-93. doi: 10.1002/adma.201304497. Epub 2013 Dec 23.
A new generation of photothermal theranostic agents is developed based on PEGylated WS2 nanosheets. Bimodal in vivo CT/photoacoustic imaging reveals strong tumor contrast after either intratumoral or intravenous injection of WS2 -PEG. In vivo photothermal treatment is then conducted in a mouse tumor model, achieving excellent therapeutic efficacy with complete ablation of tumors. This work promises further exploration of transition-metal dichalcogenides for biomedical applications, such as cancer imaging and therapy.
基于聚乙二醇化 WS2 纳米片，开发了新一代光热治疗试剂。无论是瘤内注射还是静脉注射 WS2-PEG，均可实现体内 CT/光声双模成像，肿瘤对比度均较强。随后，在小鼠肿瘤模型中进行了体内光热治疗，实现了优异的治疗效果，肿瘤完全消融。这项工作有望进一步探索过渡金属二硫属化物在癌症成像和治疗等生物医学领域的应用。
