Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, China.
Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, China.
Biochem Biophys Res Commun. 2019 Apr 9;511(3):587-591. doi: 10.1016/j.bbrc.2019.01.009. Epub 2019 Feb 26.
Tungsten disulfide (WS), which enjoyed a good potential to be a promising clinical theranostic agent for cancer treatment, is still subject to the tedious synthesis procedure.
Here, we reported a one-pot 'bottom-up' hydrothermal strategy for the fabrication of PEGylated WS nanoparticles (NPs). The WS-PEG nanoparticles were characterized systematically. The CT imaging and photothermal therapy against tumor as well as biosafety in vitro and in vivo were also investigated.
The obtained WS-PEG NPs enjoyed obvious merits of good solubility and favorable photothermal performance. WS-PEG NPs exhibited desirable photothermal ablation ability against cancer cells and cancer cell-bearing mice in vitro and in vivo. MTT assay and histological analysis demonstrated the low cytotoxicity and biotoxicity of WS-PEG NPs, providing a valid biosafety guarantee for the coming biomedical applications. In addition, thanks to the obvious X-ray attenuation of W atom, the WS-PEG NPs can also be served as a favorable contrast agent for CT imaging of tumors.
WS-PEG NPs has enjoyed a good potential to be a promising clinical CT-guided photothermal therapeutic agent against cancers.
二硫化钨 (WS) 作为一种很有前途的癌症治疗临床治疗剂，具有良好的应用潜力，但仍受到繁琐的合成工艺的限制。
本研究报道了一种用于制备聚乙二醇化 WS 纳米粒子 (NPs) 的一锅“自上而下”水热策略。系统地表征了 WS-PEG 纳米粒子。还研究了 CT 成像和光热治疗肿瘤以及体外和体内的生物安全性。
所得的 WS-PEG NPs 具有良好的溶解度和优异的光热性能等明显优点。WS-PEG NPs 在体外和体内对癌细胞和荷瘤小鼠表现出良好的光热消融能力。MTT 分析和组织学分析表明 WS-PEG NPs 的细胞毒性和生物毒性低，为即将到来的生物医学应用提供了有效的生物安全性保证。此外，由于 W 原子的明显 X 射线衰减，WS-PEG NPs 还可以用作肿瘤 CT 成像的良好造影剂。
WS-PEG NPs 很有希望成为一种有前途的临床 CT 引导光热治疗癌症的治疗剂。
