Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL, USA.
Wiley Interdiscip Rev RNA. 2014 May-Jun;5(3):335-46. doi: 10.1002/wrna.1214. Epub 2013 Dec 16.
Oxidation is probably the most common type of damage that occurs in cellular RNA. Oxidized RNA may be dysfunctional and is implicated in the pathogenesis of age-related human diseases. Cellular mechanisms controlling oxidized RNA have begun to be revealed. Currently, a number of ribonucleases and RNA-binding proteins have been shown to reduce oxidized RNA and to protect cells under oxidative stress. Although information about how these factors work is still very limited, we suggest several mechanisms that can be used to minimize oxidized RNA in various organisms.
氧化可能是细胞 RNA 中最常见的损伤类型。氧化的 RNA 可能失去功能，并与与年龄相关的人类疾病的发病机制有关。控制氧化 RNA 的细胞机制已开始被揭示。目前，已经证明许多核糖核酸酶和 RNA 结合蛋白可以减少氧化 RNA，并在氧化应激下保护细胞。尽管关于这些因素如何发挥作用的信息仍然非常有限，但我们提出了几种可以用于最大限度减少各种生物体中氧化 RNA 的机制。
