高能光子束放射治疗中光中子特性综述
A review on photoneutrons characteristics in radiation therapy with high-energy photon beams.
作者信息
Naseri Alireza, Mesbahi Asghar
机构信息
Radiation Therapy Department, Imam Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
Radiation Therapy Department, Imam Hospital, Tabriz University of Medical Sciences, Tabriz, Iran ; Medical Physics Department, Medical School, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Rep Pract Oncol Radiother. 2010 Sep 22;15(5):138-44. doi: 10.1016/j.rpor.2010.08.003.
Abstract
In radiation therapy with high-energy photon beams (E > 10 MeV) neutrons are generated mainly in linacs head thorough (γ,n) interactions of photons with nuclei of high atomic number materials that constitute the linac head and the beam collimation system. These neutrons affect the shielding requirements in radiation therapy rooms and also increase the out-of-field radiation dose of patients undergoing radiation therapy with high-energy photon beams. In the current review, the authors describe the factors influencing the neutron production for different medical linacs based on the performed measurements and Monte Carlo studies in the literature.
摘要
在使用高能光子束（E＞10 MeV）的放射治疗中，中子主要在直线加速器头部通过光子与构成直线加速器头部和射束准直系统的高原子序数材料的原子核发生（γ，n）相互作用而产生。这些中子影响放射治疗室的屏蔽要求，并且还会增加接受高能光子束放射治疗患者的野外辐射剂量。在本综述中，作者根据文献中所进行的测量和蒙特卡罗研究，描述了影响不同医用直线加速器中子产生的因素。
相似文献
1
A review on photoneutrons characteristics in radiation therapy with high-energy photon beams.高能光子束放射治疗中光中子特性综述
Rep Pract Oncol Radiother. 2010 Sep 22;15(5):138-44. doi: 10.1016/j.rpor.2010.08.003.
2
Photonuclear dose calculations for high-energy photon beams from Siemens and Varian linacs.西门子和瓦里安直线加速器高能光子束的光核剂量计算。
Med Phys. 2003 Aug;30(8):1990-2000. doi: 10.1118/1.1590436.
3
Feasibility of 18-MV grid therapy from radiation protection aspects: unwanted dose and fatal cancer risk caused by photoneutrons and scattered photons.从辐射防护角度评估 18-MV 网格治疗的可行性：光中子和散射光子所致无用剂量和致命癌症风险。
Comput Methods Programs Biomed. 2022 Jan;213:106524. doi: 10.1016/j.cmpb.2021.106524. Epub 2021 Nov 12.
4
Monte Carlo characterizations mapping of the (γ,n) and (n,γ) photonuclear reactions in the high energy X-ray radiation therapy.高能X射线放射治疗中(γ,n)和(n,γ)光核反应的蒙特卡罗特征映射
Rep Pract Oncol Radiother. 2013 Jul 31;19(1):30-6. doi: 10.1016/j.rpor.2013.07.003. eCollection 2014 Jan.
5
The effect of field modifier blocks on the fast photoneutron dose equivalent from two high-energy medical linear accelerators.射野修饰块对两台高能医用直线加速器产生的快中子剂量当量的影响。
Radiat Prot Dosimetry. 2008;128(3):359-62. doi: 10.1093/rpd/ncm421. Epub 2007 Sep 17.
6
The influence of shielding reinforcement in a vault with limited dimensions on the neutron dose equivalent in vicinity of medical electron linear accelerator.有限尺寸穹顶中屏蔽加固对医用电子直线加速器附近中子剂量当量的影响。
Radiol Oncol. 2020 May 2;54(2):247-252. doi: 10.2478/raon-2020-0024.
7
The impact of automatic wedge filter on photoneutron and photon spectra of an 18-MV photon beam.自动楔形滤过器对18兆伏光子束的光中子和光子能谱的影响。
Radiat Prot Dosimetry. 2010 Feb;138(2):123-8. doi: 10.1093/rpd/ncp204. Epub 2009 Sep 29.
8
The effect of the flattening filter on photoneutron production at 10 MV in the Varian TrueBeam linear accelerator.在瓦里安 TrueBeam 直线加速器中，10MV 时滤波板对光致中子产生的影响。
Med Phys. 2018 Oct;45(10):4711-4719. doi: 10.1002/mp.13148. Epub 2018 Sep 14.
9
Neutron dose equivalent and neutron spectra in tissue for clinical linacs operating at 15, 18 and 20 MV.15、18和20兆伏临床直线加速器在组织中的中子剂量当量和中子能谱。
Radiat Prot Dosimetry. 2011 Nov;147(4):498-511. doi: 10.1093/rpd/ncq501. Epub 2011 Jan 12.
10
Study of the photoneutron generation caused by a LinAc Beryllium window with a 6 MeV treatment beam.使用6 MeV治疗束对直线加速器铍窗产生光中子的研究。
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:4150-4153. doi: 10.1109/EMBC.2018.8513323.
引用本文的文献
1
Evaluation of a silicon carbide P-N diode for thermal neutron detection in a radiotherapy LINAC.用于放射治疗直线加速器中热中子探测的碳化硅P-N二极管的评估。
Sci Rep. 2025 Aug 20;15(1):30543. doi: 10.1038/s41598-025-13052-w.
2
A dosimetric comparison of 3D-CRT, IMRT and IMAT treatment techniques - assessment from radiation protection point of view.三维适形放疗、调强放疗和智能蒙托卡罗调强放疗技术的剂量学比较——从辐射防护角度进行评估
Rep Pract Oncol Radiother. 2024 Mar 18;29(1):69-76. doi: 10.5603/rpor.99025. eCollection 2024.
3
First independent validation of the proton-boron capture therapy concept.首次对质子硼俘获治疗概念进行独立验证。
Sci Rep. 2024 Aug 20;14(1):19264. doi: 10.1038/s41598-024-69370-y.
4
A Preliminary Investigation of Radiation-Sensitive Ultrasound Contrast Agents for Photon Dosimetry.用于光子剂量测定的辐射敏感型超声造影剂的初步研究。
Pharmaceuticals (Basel). 2024 May 14;17(5):629. doi: 10.3390/ph17050629.
5
TOPAS simulation of photoneutrons in radiotherapy: accuracy and speed with variance reduction.TOPAS 模拟放射治疗中的光中子：通过方差减少提高精度和速度。
Phys Med Biol. 2024 May 14;69(11). doi: 10.1088/1361-6560/ad4303.
6
MCNPX Estimation of Photoneutron Dose to Eye Voxel Anthropomorphic Phantom From 18 MV Linear Accelerator.利用MCNPX估算18兆伏直线加速器对眼部体素人体模型的光中子剂量
Dose Response. 2023 Apr 12;21(2):15593258231169807. doi: 10.1177/15593258231169807. eCollection 2023 Apr-Jun.
7
Study of Photoneutron Production for the 18 MV Photon Beam of the Siemens Medical linac by Monte Carlo Simulation.基于蒙特卡罗模拟的西门子医用直线加速器18 MV光子束光中子产生研究
J Biomed Phys Eng. 2020 Dec 1;10(6):679-690. doi: 10.31661/JBPE.V0I0.939. eCollection 2020 Dec.
8
Design and fabrication of a Nano-based neutron shield for fast neutrons from medical linear accelerators in radiation therapy.基于纳米的医用直线加速器辐射治疗中快中子屏蔽材料的设计与制作。
Radiat Oncol. 2020 May 11;15(1):105. doi: 10.1186/s13014-020-01551-1.
9
Monte Carlo study on the secondary cancer risk estimations for patients undergoing prostate radiotherapy: A humanoid phantom study.前列腺放疗患者继发性癌症风险估计的蒙特卡罗研究：一项人体模型研究。
Rep Pract Oncol Radiother. 2020 Mar-Apr;25(2):187-192. doi: 10.1016/j.rpor.2019.12.029. Epub 2020 Jan 10.
10
Neutron and high energy photon fluence estimation in CLINAC using gold activation foils.利用金活化箔对直线加速器中的中子和高能光子注量进行估算。
Rep Pract Oncol Radiother. 2019 Jan-Feb;24(1):41-46. doi: 10.1016/j.rpor.2018.08.009. Epub 2018 Oct 11.
本文引用的文献
1
The impact of automatic wedge filter on photoneutron and photon spectra of an 18-MV photon beam.自动楔形滤过器对18兆伏光子束的光中子和光子能谱的影响。
Radiat Prot Dosimetry. 2010 Feb;138(2):123-8. doi: 10.1093/rpd/ncp204. Epub 2009 Sep 29.
2
Effect of wedge filter and field size on photoneutron dose equivalent for an 18MV photon beam of a medical linear accelerator.楔形滤过器和射野大小对医用直线加速器18MV光子束光中子剂量当量的影响。
Appl Radiat Isot. 2010 Jan;68(1):84-9. doi: 10.1016/j.apradiso.2009.08.008. Epub 2009 Aug 25.
3
Monte Carlo estimation of photoneutrons contamination from high-energy X-ray medical accelerators in treatment room and maze: a simplified model.治疗室和迷宫中高能X射线医用加速器产生的光中子污染的蒙特卡罗估计：一个简化模型。
Radiat Prot Dosimetry. 2009 Jul;135(1):21-32. doi: 10.1093/rpd/ncp097. Epub 2009 May 30.
4
Spectra of photoneutrons produced by high-energy X-ray radiotherapy linacs.高能X射线放射治疗直线加速器产生的光中子能谱。
Radiat Prot Dosimetry. 2008;132(1):13-7. doi: 10.1093/rpd/ncn278. Epub 2008 Oct 20.
5
A Monte Carlo study on neutron and electron contamination of an unflattened 18-MV photon beam.关于非均整18兆伏光子束中子和电子污染的蒙特卡罗研究。
Appl Radiat Isot. 2009 Jan;67(1):55-60. doi: 10.1016/j.apradiso.2008.07.013. Epub 2008 Jul 25.
6
Monte Carlo study on a flattening filter-free 18-MV photon beam of a medical linear accelerator.医用直线加速器无均整器18兆伏光子束的蒙特卡罗研究
Radiat Med. 2008 Jul;26(6):331-6. doi: 10.1007/s11604-008-0234-y. Epub 2008 Aug 3.
7
Energy spectra, sources, and shielding considerations for neutrons generated by a flattening filter-free Clinac.无均整器直线加速器产生的中子的能谱、来源及屏蔽考量
Med Phys. 2008 May;35(5):1906-11. doi: 10.1118/1.2905029.
8
Measurement of the neutron leakage from a dedicated intraoperative radiation therapy electron linear accelerator and a conventional linear accelerator for 9, 12, 15(16), and 18(20) MeV electron energies.测量专用术中放射治疗电子直线加速器和传统直线加速器在9、12、15（16）和18（20）兆电子伏特电子能量下的中子泄漏情况。
Med Phys. 2008 May;35(5):1711-7. doi: 10.1118/1.2898144.
9
Measurement of photoneutron dose produced by wedge filters of a high energy linac using polycarbonate films.使用聚碳酸酯薄膜测量高能直线加速器楔形滤过器产生的光中子剂量。
J Radiat Res. 2008 May;49(3):279-83. doi: 10.1269/jrr.07066. Epub 2008 May 3.
10
Monte Carlo determination of radiation-induced cancer risks for prostate patients undergoing intensity- modulated radiation therapy.蒙特卡洛法确定接受调强放射治疗的前列腺癌患者的辐射诱发癌症风险
J Appl Clin Med Phys. 2007 Sep 17;8(4):14-27. doi: 10.1120/jacmp.v8i4.2685.
Zotero 插件