Department of Pediatrics, Santa Maria Hospital, Lisbon Academic Medical Centre, Portugal2Clinical Pharmacology Unit, Instituto de Medicina Molecular, University of Lisbon, Portugal.
Department of Pediatrics, Alberta Research Centre for Health Evidence, University of Alberta, Edmonton, Canada.
JAMA. 2014 Jan 1;311(1):87-8. doi: 10.1001/jama.2013.284921.
Are glucocorticoids, alone or combined with bronchodilators, associated with reduced admission rates, length of stay, or improvements in clinical severity scores without increased adverse effects in infants and young children with acute viral bronchiolitis?
There is no consistent clinically relevant association of single therapy with systemic or inhaled glucocorticoids and improved outcomes in either outpatient or inpatient settings. Exploratory evidence suggests that combined glucocorticoids and nebulized epinephrine may be associated with lower hospitalization rates in outpatients, but these findings must be interpreted cautiously.
糖皮质激素单独或联合支气管扩张剂是否与降低急性病毒性细支气管炎婴儿和幼儿的住院率、住院时间或临床严重程度评分改善相关，同时不增加不良反应？
在门诊或住院环境中，单一疗法与全身或吸入性糖皮质激素均无一致的临床相关关联，可改善结局。探索性证据表明，糖皮质激素联合雾化肾上腺素可能与降低门诊患者的住院率相关，但这些发现必须谨慎解释。
