Jolkkonen J, Lehtinen M, Soininen H, Sennef C, Riekkinen P
Neurosci Lett. 1987 May 19;76(3):312-5. doi: 10.1016/0304-3940(87)90421-6.
The effect of desglycinamide-arginine-vasopressin (DGAVP) on monoaminergic neurotransmission was studied in human subjects. Samples of cerebrospinal fluid (CSF) were collected during 240 min after DGAVP (2 mg) had been administered intranasally, and monoamine metabolites in CSF were measured with HPLC using electrochemical detection. Levels of homovanillic acid and 5-hydroxyindoleacetic acid increased (P less than 0.05) 150 min after DGAVP administration, whereas levels of 3-methoxy-4-hydroxyphenylglycol were stable during the time monitored. These results suggest that in human subjects the mechanism of action of DGAVP may involve dopaminergic and serotonergic systems.
在人体受试者中研究了去甘氨酰胺-精氨酸-加压素（DGAVP）对单胺能神经传递的影响。在经鼻给予DGAVP（2毫克）后的240分钟内收集脑脊液（CSF）样本，并使用电化学检测的高效液相色谱法测量CSF中的单胺代谢物。给予DGAVP 150分钟后，高香草酸和5-羟基吲哚乙酸水平升高（P小于0.05），而在监测期间3-甲氧基-4-羟基苯乙二醇水平稳定。这些结果表明，在人体受试者中，DGAVP的作用机制可能涉及多巴胺能和5-羟色胺能系统。
