成年小鼠中一个Qa区域基因的广泛转录。
Widespread transcription of a Qa region gene in adult mice.
作者信息
Palmer M J, Frelinger J A
出版信息
J Exp Med. 1987 Jul 1;166(1):95-108. doi: 10.1084/jem.166.1.95.
Abstract
The mouse MHC class I family includes genes encoded in four regions: H-2K, H-2D, Qa and Tla. While K/D genes are well characterized, relatively little is known about Qa or Tla genes. We have studied the transcription of a B10.P Qa region gene. DNA sequence comparisons of the transmembrane region, supported by Southern blot analysis of cosmid and genomic DNAs from BALB/c and C57BL/10, demonstrate the lambda 3a gene corresponds to Q4p. In both Northern blots and RNA protection experiments using probes derived from the 3' noncoding region, we found that Q4, like the H-2K and H-2D genes, is widely transcribed in B10.P tissues. These data demonstrate for the first time widespread transcription of a Qa gene.
摘要
小鼠MHC I类基因家族包括在四个区域编码的基因：H-2K、H-2D、Qa和Tla。虽然K/D基因已得到充分表征，但对Qa或Tla基因的了解相对较少。我们研究了B10.P Qa区域基因的转录。通过对跨膜区域的DNA序列比较，并辅以来自BALB/c和C57BL/10的黏粒和基因组DNA的Southern印迹分析，证明λ3a基因对应于Q4p。在使用源自3'非编码区的探针进行的Northern印迹和RNA保护实验中，我们发现Q4与H-2K和H-2D基因一样，在B10.P组织中广泛转录。这些数据首次证明了Qa基因的广泛转录。
相似文献
1
Widespread transcription of a Qa region gene in adult mice.成年小鼠中一个Qa区域基因的广泛转录。
J Exp Med. 1987 Jul 1;166(1):95-108. doi: 10.1084/jem.166.1.95.
2
Organization of the AKR Qa region: structure of a divergent class I sequence, Q5k.AKR Qa区域的组织：一个 divergent I类序列Q5k的结构
J Immunogenet. 1989 Aug-Oct;16(4-5):283-90. doi: 10.1111/j.1744-313x.1989.tb00474.x.
3
Evolution and expression of the transplantation antigen gene family.移植抗原基因家族的进化与表达
Fed Proc. 1985 Aug;44(11):2736-40.
4
Conservation and diversity in the class I genes of the major histocompatibility complex: sequence analysis of a Tlab gene and comparison with a Tlac gene.主要组织相容性复合体I类基因的保守性与多样性：一个Tlab基因的序列分析及与一个Tlac基因的比较
Proc Natl Acad Sci U S A. 1986 Mar;83(6):1782-6. doi: 10.1073/pnas.83.6.1782.
5
Expression and T cell recognition of hybrid antigens with amino-terminal domains encoded by Qa-2 region of major histocompatibility complex and carboxyl termini of transplantation antigens.具有由主要组织相容性复合体Qa-2区域编码的氨基末端结构域和移植抗原羧基末端的杂合抗原的表达及T细胞识别
J Exp Med. 1985 May 1;161(5):935-52. doi: 10.1084/jem.161.5.935.
6
Expression of the Qa-2k phenotype encoded by the Q5k gene on the surface of tumor cells derived from H-2k mice.由Q5k基因编码的Qa - 2k表型在源自H - 2k小鼠的肿瘤细胞表面的表达。
J Exp Med. 1992 Mar 1;175(3):647-54. doi: 10.1084/jem.175.3.647.
7
Tumor cell-specific transcription of a murine histocompatibility class Ib Q5 gene.小鼠组织相容性 Ib 类 Q5 基因的肿瘤细胞特异性转录
Anticancer Res. 2004 Sep-Oct;24(5C):3379-86.
8
9
10
Organization and evolution of D region class I genes in the mouse major histocompatibility complex.小鼠主要组织相容性复合体中I类D区基因的组织与进化
J Exp Med. 1986 May 1;163(5):1227-44. doi: 10.1084/jem.163.5.1227.
引用本文的文献
1
Baseline gene expression in BALB/c and C57BL/6 peritoneal macrophages influences but does not dictate their functional phenotypes.BALB/c和C57BL/6腹膜巨噬细胞中的基线基因表达会影响但不会决定它们的功能表型。
Exp Biol Med (Maywood). 2025 Jan 3;249:10377. doi: 10.3389/ebm.2024.10377. eCollection 2024.
2
A physical map of the Q region of B1O.P.B1O.P.的Q区域的物理图谱
Mamm Genome. 1996 Mar;7(3):200-5. doi: 10.1007/s003359900054.
3
A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.一种人类主要组织相容性复合体I类基因，其编码一种具有缩短细胞质区段的蛋白质。
Proc Natl Acad Sci U S A. 1987 Dec;84(24):9145-9. doi: 10.1073/pnas.84.24.9145.
4
Signaling to a B-cell clone by Ek, but not Ak, does not reflect alteration of Ak genes.由Ek而非Ak向B细胞克隆发出信号，并不反映Ak基因的改变。
Immunogenetics. 1988;28(3):184-92. doi: 10.1007/BF00375858.
5
Organization and structure of the Qa genes of the major histocompatibility complex of the C3H mouse: implications for Qa function and class I evolution.C3H小鼠主要组织相容性复合体Qa基因的组织与结构：对Qa功能及I类基因进化的启示
EMBO J. 1989 Jun;8(6):1749-59. doi: 10.1002/j.1460-2075.1989.tb03568.x.
6
Genetics and expression of the Q6 and Q8 genes. An LTR-like sequence in the 3' untranslated region.Q6和Q8基因的遗传学与表达。3'非翻译区中的一个类似长末端重复序列（LTR）的序列。
Immunogenetics. 1989;29(6):371-9. doi: 10.1007/BF00375865.
7
Polymorphism in the human class I MHC locus HLA-E in Japanese.
Immunogenetics. 1990;32(3):205-9. doi: 10.1007/BF02114975.
本文引用的文献
1
DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen.编码BALB/c小鼠Ld移植抗原的基因的DNA序列。
Science. 1982 Feb 5;215(4533):679-82. doi: 10.1126/science.7058332.
2
Tissue-specific expression of an unusual H-2 (class I)-related gene.一个不寻常的与H-2（I类）相关基因的组织特异性表达。
Proc Natl Acad Sci U S A. 1982 Aug;79(16):4947-51. doi: 10.1073/pnas.79.16.4947.
3
A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains.一个与小鼠移植抗原同源的假基因：移植抗原由与蛋白质结构域相关的八个外显子编码。
Cell. 1981 Sep;25(3):683-92. doi: 10.1016/0092-8674(81)90175-6.
4
Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer.通过DNA介导的基因转移鉴定小鼠主要组织相容性复合体的I类基因。
Nature. 1982 Nov 18;300(5889):231-7. doi: 10.1038/300231a0.
5
Most early-variant histone mRNA is contained in the pronucleus of sea urchin eggs.大多数早期变体组蛋白mRNA包含在海胆卵的原核中。
Dev Biol. 1983 Nov;100(1):197-206. doi: 10.1016/0012-1606(83)90211-7.
6
A potential donor gene for the bm1 gene conversion event in the C57BL mouse.C57BL小鼠中bm1基因转换事件的一个潜在供体基因。
Nature. 1983;306(5945):792-5. doi: 10.1038/306792a0.
7
Detection of a secreted form of the murine H-2 class I antigen with an antibody against its predicted carboxyl terminus.利用针对小鼠H-2 I类抗原预测羧基末端的抗体检测其分泌形式。
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1216-20. doi: 10.1073/pnas.81.4.1216.
8
A nonpolymorphic class I gene in the murine major histocompatibility complex.小鼠主要组织相容性复合体中的一个非多态性I类基因。
Cell. 1984 Jan;36(1):139-44. doi: 10.1016/0092-8674(84)90082-5.
9
Secretion of a transplantation-related antigen.一种移植相关抗原的分泌。
Cell. 1983 Aug;34(1):189-96. doi: 10.1016/0092-8674(83)90149-6.
10
Cloning and identification of the H-2Dp gene.H-2Dp基因的克隆与鉴定
Immunogenetics. 1984;19(3):195-204. doi: 10.1007/BF00364763.
Zotero 插件