Tseng Marion, Fratamico Pina M, Manning Shannon D, Funk Julie A
College of Veterinary Medicine, Michigan State University,East Lansing, MI 48824,USA.
Eastern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture,Wyndmoor, PA 19038,USA.
Anim Health Res Rev. 2014 Jun;15(1):63-75. doi: 10.1017/S1466252313000170. Epub 2014 Jan 8.
Shiga toxin-producing Escherichia coli (STEC) strains are food-borne pathogens that are an important public health concern. STEC infection is associated with severe clinical diseases in human beings, including hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS), which can lead to kidney failure and death. Cattle are the most important STEC reservoir. However, a number of STEC outbreaks and HUS cases have been attributed to pork products. In swine, STEC strains are known to be associated with edema disease. Nevertheless, the relationship between STEC of swine origin and human illness has yet to be determined. This review critically summarizes epidemiologic and biological studies of swine STEC. Several epidemiologic studies conducted in multiple regions of the world have demonstrated that domestic swine can carry and shed STEC. Moreover, animal studies have demonstrated that swine are susceptible to STEC O157:H7 infection and can shed the bacterium for 2 months. A limited number of molecular epidemiologic studies, however, have provided conflicting evidence regarding the relationship between swine STEC and human illness. The role that swine play in STEC transmission to people and the contribution to human disease frequency requires further evaluation.
产志贺毒素大肠杆菌（STEC）菌株是食源性病原体，是一个重要的公共卫生问题。STEC感染与人类严重的临床疾病有关，包括出血性结肠炎（HC）和溶血尿毒综合征（HUS），这可能导致肾衰竭和死亡。牛是最重要的STEC宿主。然而，一些STEC疫情爆发和HUS病例已归因于猪肉产品。在猪中，STEC菌株已知与水肿病有关。尽管如此，猪源STEC与人类疾病之间的关系尚未确定。这篇综述批判性地总结了猪STEC的流行病学和生物学研究。在世界多个地区进行的几项流行病学研究表明，家猪可以携带和排出STEC。此外，动物研究表明，猪易受STEC O157:H7感染，并且可以在2个月内排出这种细菌。然而，有限数量的分子流行病学研究提供了关于猪STEC与人类疾病之间关系的相互矛盾的证据。猪在STEC传播给人类中的作用以及对人类疾病发生率的贡献需要进一步评估。
