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2型糖尿病患者成年子女的遗传咨询对其糖尿病态度及其遗传的影响:一项随机对照试验。

The effect of genetic counseling for adult offspring of patients with type 2 diabetes on attitudes toward diabetes and its heredity: a randomized controlled trial.

作者信息

Nishigaki M, Tokunaga-Nakawatase Y, Nishida J, Kazuma K

机构信息

The Graduate School of Medicine, School of Health Sciences and Nursing, Department of Adult Nursing, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan,

出版信息

J Genet Couns. 2014 Oct;23(5):762-9. doi: 10.1007/s10897-013-9680-5. Epub 2014 Jan 8.

Abstract

The aim of this study is to investigate the effect of diabetes genetic counseling on attitudes toward diabetes and its heredity in relatives of type 2 diabetes patients. This study was an unmasked, randomized controlled trial at a medical check-up center in Japan. Subjects in this study are healthy adults between 30 and 60 years of age who have a family history of type 2 diabetes in their first degree relatives. Participants in the intervention group received a brief genetic counseling session for approximately 10 min. Genetic counseling was structured based on the Health Belief Model. Both intervention and control groups received a booklet for general diabetes prevention. Risk perception and recognition of diabetes, and attitude towards its prevention were measured at baseline, 1 week and 1 year after genetic counseling. Participants who received genetic counseling showed significantly higher recognition about their sense of control over diabetes onset than control group both at 1 week and 1 year after the session. On the other hand, anxiety about diabetes did not change significantly. The findings show that genetic counseling for diabetes at a medical check center helped adults with diabetes family history understand they are able to exert control over the onset of their disease through lifestyle modification.

摘要

本研究的目的是调查糖尿病遗传咨询对2型糖尿病患者亲属对糖尿病及其遗传的态度的影响。本研究是在日本一家体检中心进行的一项非盲法随机对照试验。本研究的受试者是30至60岁的健康成年人,他们的一级亲属中有2型糖尿病家族史。干预组的参与者接受了约10分钟的简短遗传咨询。遗传咨询是基于健康信念模型构建的。干预组和对照组都收到了一本关于一般糖尿病预防的小册子。在遗传咨询前、咨询后1周和1年后测量糖尿病的风险认知和识别以及对其预防的态度。接受遗传咨询的参与者在咨询后1周和1年时,对糖尿病发病的控制感的认知明显高于对照组。另一方面,对糖尿病的焦虑没有显著变化。研究结果表明,在体检中心进行的糖尿病遗传咨询有助于有糖尿病家族史的成年人了解他们能够通过改变生活方式来控制疾病的发生。

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