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腹泻后继发突发性聋:缺失的环节是什么?

Sudden hearing loss subsequent to diarrhea: what is the missing link?

机构信息

Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Daru. 2014 Jan 8;22(1):15. doi: 10.1186/2008-2231-22-15.

Abstract

Sudden sensorineural hearing loss (SSNHL) is a debilitating condition with an incidence of nearly 20 per 100,000 in populations. Metronidazole-induced ototoxicity is an extremely rare etiology of SSNHL. In this report, we describe a young female with bilateral SSNHL due to oral use of metronidazole. A 23 years old female presented to the emergency department with acute bilateral hearing loss. We found out that her hearing loss had started 4 days after initiation of metronidazole which was administered for treatment of diarrhea. This case report shows that physicians should be aware of the uncommon side effects while prescribing metronidazole to patients in order to manage the possible adverse events on time.

摘要

突发性聋(SSNHL)是一种使人虚弱的疾病,其发病率接近每 10 万人中有 20 人。甲硝唑诱导的耳毒性是 SSNHL 的一种极罕见病因。在本报告中,我们描述了一名因口服甲硝唑而导致双侧 SSNHL 的年轻女性。一名 23 岁女性因急性双侧听力丧失到急诊科就诊。我们发现她的听力丧失始于甲硝唑开始使用的 4 天前,甲硝唑用于治疗腹泻。本病例报告表明,医生在给患者开具甲硝唑处方时应注意其不常见的副作用,以便及时处理可能的不良事件。

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本文引用的文献

1
Clinical practice guideline: sudden hearing loss.临床实践指南:突发性聋。
Otolaryngol Head Neck Surg. 2012 Mar;146(3 Suppl):S1-35. doi: 10.1177/0194599812436449.
6
Metronidazole ototoxicity--report of two cases.甲硝唑耳毒性——两例报告。
J Laryngol Otol. 1999 Apr;113(4):355-7. doi: 10.1017/s0022215100143968.
8
Natural history of sudden sensorineural hearing loss.
Ann Otol Rhinol Laryngol. 1977 Jul-Aug;86(4 Pt 1):463-80. doi: 10.1177/000348947708600406.

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