Jedrziewski M Kathryn, Ewbank Douglas C, Wang Haidong, Trojanowski John Q
The Institute on Aging, University of Pennsylvania, Philadelphia, PA, USA Marian S. Ware Alzheimer Program, University of Pennsylvania, Philadelphia, PA, USA Alzheimer's Disease Core Center, University of Pennsylvania, Philadelphia, PA, USA Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Population Studies Center, University of Pennsylvania, Philadelphia, PA, USA.
Am J Alzheimers Dis Other Demen. 2014 Jun;29(4):372-8. doi: 10.1177/1533317513518646. Epub 2014 Jan 8.
Currently, there are no effective treatments for Alzheimer's disease and related disorders and age continues to be a robust risk factor. Thus, population aging in the United States may have catastrophic results if interventions are not found and implemented. This study examines possible associations between cognitive impairment and exercise, cognitive activities, and socialization. Cognitive activities, socialization, and exercise were assessed at baseline, and cognitive function was measured at baseline, 5-year, and 10-year follow-up. Controlling for baseline cognitive function, age, sex, education, diabetes, and hypertension, linear regression was performed. Engagement in cognitive activities was inversely associated with the onset of cognitive impairment at 5-year follow-up but was no longer significant at 10-year follow-up. Exercise was associated with a lower risk of cognitive impairment at 10-year follow-up but was not significant at 5-year follow-up. Associations with socialization were not statistically significant at either follow-up.
目前,尚无针对阿尔茨海默病及相关疾病的有效治疗方法,而年龄仍然是一个重要的风险因素。因此,如果找不到并实施干预措施,美国的人口老龄化可能会带来灾难性后果。本研究探讨了认知障碍与运动、认知活动及社交之间可能存在的关联。在基线时评估了认知活动、社交和运动情况,并在基线、5年和10年随访时测量了认知功能。在控制了基线认知功能、年龄、性别、教育程度、糖尿病和高血压后,进行了线性回归分析。在5年随访时,参与认知活动与认知障碍的发生呈负相关,但在10年随访时不再显著。在10年随访时,运动与认知障碍风险较低相关,但在5年随访时不显著。在两次随访中,与社交的关联均无统计学意义。