Division of Medical Sciences, University of Victoria Victoria, BC, Canada.
Division of Medical Sciences, University of Victoria Victoria, BC, Canada ; Department of Biology, University of Victoria Victoria, BC, Canada ; Department of Biochemistry and Microbiology, University of Victoria Victoria, BC, Canada ; Department of Cellular and Physiological Sciences and Island Medical Program, University of British Columbia Vancouver, BC, Canada.
Front Cell Neurosci. 2014 Jan 8;7:287. doi: 10.3389/fncel.2013.00287.
Pannexins (Panxs) are a family of single-membrane, large-pore ion, and metabolite permeable channels. Of the three Panx proteins, Panx1 has been most extensively studied, and has recently emerged as an exciting, clinically relevant target in many physiological and pathophysiological settings. This channel is widely expressed across various cell and tissue types; however its links to precise signaling pathways are largely unknown. Here we review the current literature surrounding presently identified Panx1-protein interactions, a critical first step to unraveling the Panx1 signalome. First we elucidate the reported associations of Panx1 with other ion channels, receptors, and channel signaling complexes. Further, we highlight recently identified Panx1-cytoskeleton interactions. Finally, we discuss the implications of these protein-protein interactions for Panx1 function in various cell and tissue types, and identify key outstanding questions arising from this work.
连接蛋白（Panx）是一类具有单一膜、大孔离子和代谢物通透性的通道。在三种连接蛋白中，连接蛋白 1（Panx1）的研究最为广泛，最近在许多生理和病理生理环境中成为一个令人兴奋的、具有临床相关性的靶点。该通道在各种细胞和组织类型中广泛表达；然而，其与精确信号通路的联系在很大程度上尚不清楚。在这里，我们回顾了目前围绕着现已确定的连接蛋白 1-蛋白相互作用的文献，这是阐明连接蛋白 1 信号组学的关键第一步。首先，我们阐明了连接蛋白 1 与其他离子通道、受体和通道信号复合物的报告关联。此外，我们还重点介绍了最近发现的连接蛋白 1-细胞骨架相互作用。最后，我们讨论了这些蛋白-蛋白相互作用对连接蛋白 1 在各种细胞和组织类型中的功能的影响，并确定了这项工作中出现的关键问题。
