强大的伙伴关系：泛连接蛋白1与细胞骨架之间的相互作用
Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton.
作者信息
Boyce Andrew K J, Wicki-Stordeur Leigh E, Swayne Leigh Anne
机构信息
Division of Medical Sciences, University of Victoria Victoria, BC, Canada.
Division of Medical Sciences, University of Victoria Victoria, BC, Canada ; Department of Biology, University of Victoria Victoria, BC, Canada ; Department of Biochemistry and Microbiology, University of Victoria Victoria, BC, Canada ; Department of Cellular and Physiological Sciences and Island Medical Program, University of British Columbia Vancouver, BC, Canada.
出版信息
Front Physiol. 2014 Jan 30;5:27. doi: 10.3389/fphys.2014.00027. eCollection 2014.
The roles of pannexin 1 (Panx1) large-pore ion and metabolite channels are becoming recognized in many physiological and pathophysiological scenarios. Recent evidence has tightly linked Panx1 trafficking and function to the cytoskeleton, a multi-component network that provides critical structural support, transportation, and scaffolding functions in all cell types. Here we review early work demonstrating the mechanosensitive activation of Panx1 channels, and expand on more recent evidence directly linking Panx1 to the cytoskeleton. Further, we examine the reciprocal regulation between Panx1 and the cytoskeleton, and discuss the involvement of Panx1 in cytoskeletal-regulated cell behaviors. Finally, we identify important gaps in the current knowledge surrounding this emerging Panx1-cytoskeleton relationship.
在许多生理和病理生理情况下，泛连接蛋白1（Panx1）大孔离子通道和代谢物通道的作用正逐渐得到认可。最近的证据表明，Panx1的运输和功能与细胞骨架紧密相连，细胞骨架是一个多组分网络，在所有细胞类型中提供关键的结构支持、运输和支架功能。在这里，我们回顾了早期证明Panx1通道机械敏感性激活的研究工作，并进一步阐述了将Panx1与细胞骨架直接联系起来的最新证据。此外，我们研究了Panx1与细胞骨架之间的相互调节，并讨论了Panx1在细胞骨架调节的细胞行为中的作用。最后，我们指出了围绕这种新兴的Panx1-细胞骨架关系的当前知识中的重要空白。
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