Department of Neurosciences, University of California , San Diego, CA , USA.
Cognitive Science Department, University of California , San Diego, CA , USA ; Swartz Center for Computational Neuroscience, University of California , San Diego, CA , USA ; Institute for Neural Computation, University of California , San Diego, CA , USA.
Front Neurol. 2014 Jan 9;4:209. doi: 10.3389/fneur.2013.00209. eCollection 2014.
Freezing of gait (FOG) is an elusive phenomenon that debilitates a large number of Parkinson's disease (PD) patients regardless of stage of disease, medication status, or deep brain stimulation implantation. Sensory feedback cues, especially visual feedback cues, have been shown to alleviate FOG episodes or even prevent episodes from occurring. Here, we examine cortical information flow between occipital, parietal, and motor areas during the pre-movement stage of gait in a PD-with-FOG patient that had a strong positive behavioral response to visual cues, one PD-with-FOG patient without any behavioral response to visual cues, and age-matched healthy controls, before and after training with visual feedback. Results for this case study show differences in cortical information flow between the responding PD-with-FOG patient and the other two subject types, notably, an increased information flow in the beta range. Tentatively suggesting the formation of an alternative cortical sensory-motor pathway during training with visual feedback, these results are proposed as subject for further verification employing larger cohorts of patients.
冻结步态（FOG）是一种难以捉摸的现象，它使大量帕金森病（PD）患者身体虚弱，无论疾病处于哪个阶段、药物状态如何或是否进行了深部脑刺激植入。已经证明，感觉反馈线索，特别是视觉反馈线索，可以减轻 FOG 发作，甚至可以防止发作发生。在这里，我们在 PD 伴有 FOG 患者的运动前阶段检查了枕叶、顶叶和运动区域之间的皮质信息流，该患者对视觉线索有强烈的积极行为反应，PD 伴有 FOG 患者对视觉线索没有任何行为反应，以及年龄匹配的健康对照者，在接受视觉反馈训练前后。这项案例研究的结果表明，对视觉线索有反应的 PD 伴有 FOG 患者与其他两种类型的患者之间皮质信息流存在差异，特别是β频带的信息流增加。这暂时表明在视觉反馈训练过程中形成了替代的皮质感觉运动通路，这些结果被提出作为进一步使用更大患者队列进行验证的主题。
