Tsujimoto M, Ueda T, Nakashima H, Hamada H, Ishiguro S, Aozasa K
Acta Pathol Jpn. 1987 Apr;37(4):597-604. doi: 10.1111/j.1440-1827.1987.tb00393.x.
Seven cases of synovial sarcoma (SS), two with biphasic and five with monophasic histology, were studied immunohistochemically using monoclonal antibodies to intermediate filaments, keratin, and vimentin. Slender spindle cells and plump cells were constant components of all the tumors. Epithelioid cells were present only in biphasic SS. Epithelioid cells and plump cells were positively stained by both keratin and vimentin. Slender spindle cells were stained positive for vimentin and negative for keratin. Staining manner of each cell type was similar irrespective of monophasic or biphasic pattern. Present immunohistochemical studies suggested that monophasic or biphasic patterns in SS should be regarded as a different expression of the same disease. In addition, immunohistochemistry proved to be a useful tool to detect plump cells which were difficult to find on routine staining.
对7例滑膜肉瘤（SS）进行了免疫组织化学研究，其中2例为双相型，5例为单相型，使用针对中间丝、角蛋白和波形蛋白的单克隆抗体。细长梭形细胞和饱满细胞是所有肿瘤的恒定组成成分。上皮样细胞仅存在于双相型滑膜肉瘤中。上皮样细胞和饱满细胞对角蛋白和波形蛋白均呈阳性染色。细长梭形细胞波形蛋白染色呈阳性，角蛋白染色呈阴性。无论单相型或双相型模式，每种细胞类型的染色方式相似。目前的免疫组织化学研究表明，滑膜肉瘤的单相型或双相型模式应被视为同一种疾病的不同表现形式。此外，免疫组织化学被证明是检测常规染色难以发现的饱满细胞的有用工具。
