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上皮样肉瘤的细胞分化。一项电子显微镜、酶组织化学和免疫组织化学研究。

Cellular differentiation of epithelioid sarcoma. An electron-microscopic, enzyme-histochemical, and immunohistochemical study.

作者信息

Mukai M, Torikata C, Iri H, Hanaoka H, Kawai T, Yakumaru K, Shimoda T, Mikata A, Kageyama K

出版信息

Am J Pathol. 1985 Apr;119(1):44-56.

PMID:2580443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1888074/
Abstract

For the purpose of clarifying cellular differentiation of epithelioid sarcoma, studies based on various methods were performed. Enzyme histochemical studies showed that epithelioid sarcoma tumor cells have characteristics intermediate between epithelial cells and the large plump cells of synovial sarcoma-incomplete epithelial differentiation. For alkaline phosphatase and adenosine triphosphatase particularly, positive cells and negative cells coexisted, as in the large plump cells of synovial sarcoma. Immunohistochemical studies for alpha 1-antitrypsin, alpha 1-antichymotrypsin, vimentin, and keratin also showed that epithelioid sarcoma tumor cells are very similar to the large plump cells of synovial sarcoma and have incomplete epithelial differentiation. For example, the examinations of serial sections and double staining methods revealed that keratin-positive cells are always vimentin-positive in epithelioid sarcoma and in the monophasic area of synovial sarcoma. Electron-microscopically, bundles of intermediate filaments and filopodia toward the intercellular lumen were observed, as in the monophasic area of synovial sarcoma. The results of enzyme-histochemical and immunohistochemical studies of non-neoplastic synovial lining cells, performed here for the first time, are also discussed.

摘要

为了阐明上皮样肉瘤的细胞分化情况，我们采用了多种方法进行研究。酶组织化学研究表明，上皮样肉瘤肿瘤细胞具有介于上皮细胞和滑膜肉瘤大而饱满细胞之间的特征——不完全上皮分化。特别是对于碱性磷酸酶和三磷酸腺苷酶，阳性细胞和阴性细胞共存，就像滑膜肉瘤的大而饱满细胞一样。针对α1 -抗胰蛋白酶、α1 -抗糜蛋白酶、波形蛋白和角蛋白的免疫组织化学研究也表明，上皮样肉瘤肿瘤细胞与滑膜肉瘤的大而饱满细胞非常相似，且具有不完全上皮分化。例如，连续切片检查和双重染色方法显示，在上皮样肉瘤和滑膜肉瘤单相区域中，角蛋白阳性细胞总是波形蛋白阳性。电子显微镜下，观察到中间丝束和朝向细胞间腔的丝状伪足，这与滑膜肉瘤单相区域的情况相同。本文首次对非肿瘤性滑膜衬里细胞进行的酶组织化学和免疫组织化学研究结果也进行了讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/780b/1888074/f0fd2afc25f7/amjpathol00169-0060-b.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/780b/1888074/19de241d903b/amjpathol00169-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/780b/1888074/89aed07a9712/amjpathol00169-0052-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/780b/1888074/7e087e668382/amjpathol00169-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/780b/1888074/29a4c0e83b0c/amjpathol00169-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/780b/1888074/b257c85e9458/amjpathol00169-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/780b/1888074/7e826ace83a6/amjpathol00169-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/780b/1888074/5b15dc527a79/amjpathol00169-0057-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/780b/1888074/f77154a2f03c/amjpathol00169-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/780b/1888074/3a5ce4edf000/amjpathol00169-0059-a.jpg
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