Brindle Cheyenne S, Yeung Charles S, Jacobsen Eric N
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
Chem Sci J. 2013 May 1;4(5). doi: 10.1039/C3SC50410G.
Highly enantioselective vicinal iodoamination of olefins is accomplished through the iodocyclization of alkenyl trichloroacetimidates catalyzed by a new chiral Schiff-base urea derivative. The resulting products are converted readily to a variety of polyfunctional amine-containing chiral building blocks.
通过一种新型手性席夫碱脲衍生物催化的链烯基三氯乙酰亚胺酯的碘环化反应，实现了烯烃的高度对映选择性邻位碘胺化反应。所得产物可轻松转化为多种含多官能团胺的手性结构单元。
